{"doi":"10.1080/14756360701654894","title":"Effects of hydroxybenzyl alcohols on melanogenesis in melanocyte-keratinocyte co-culture and monolayer culture of melanocytes","abstract":null,"journal":"Journal of Enzyme Inhibition and Medicinal Chemistry","year":2008,"id":684575,"datarank":0.40620753016533157,"base_score":2.70805020110221,"endowment":2.70805020110221,"self_citation_contribution":0.40620753016533157,"citation_network_contribution":0.0,"self_endowment_contribution":0.40620753016533157,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":1,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1624140,"name":"I-Ming Chu","orcid":null,"position":1,"is_corresponding":false},{"id":1788434,"name":"I-Horng Pan","orcid":null,"position":2,"is_corresponding":false},{"id":1788433,"name":"Szu-Hsiu Liu","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Effects of hydroxybenzyl alcohols on melanogenesis in melanocyte-keratinocyte co-culture and monolayer culture of melanocytes","abstract":"In mammalian skin, melanocyte proliferation and melanogenesis can be stimulated by keratinocytes, fibroblasts and other regulatory factors. To determine whether hydroxybenzyl alcohols (HBAs) show more inhibitory in melanocytes cultured alone or in melanocytes co-cultured with keratinocytes, we developed a murine melanocyte-keratinocyte co-culture model to investigate the pigmentation regulators in company with other melanogenic inhibitors and stimulators. It was found that the effects of HBAs and melanogenic factors were more evident in melanocytes co-cultured with keratinocytes. Keratinocytes may play a synergistic role in melanocyte melanogenesis and influence the pigment production. The tests in the co-culture model also imply that the inhibitory effects of HBAs on melanogenesis are due to the direct inhibition of melanosomal tyrosinase activity. HBAs showed a low cytotoxicity. The eventual results proved that HBAs are promising and safe agents for skin whitening in melanocyte alone and in co-culture systems. The co-culture model provides a more physiologically realistic condition to study the interaction between melanocytes and keratinocytes, which enables a reliable screening system for depigmenting compounds.","is_dataset_classified":null,"base_score":2.70805020110221,"endowment":2.70805020110221,"datacite_reuse_total":1,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18666000","pmcid":null,"openalex_id":"https://openalex.org/W1994336586","authors":[],"funders":[],"total_grants":0,"fwci":0.38,"citation_percentile":0.58325863,"influential_citations":0,"citation_trend":[{"year":2013,"count":1},{"year":2015,"count":1},{"year":2016,"count":1},{"year":2018,"count":1},{"year":2019,"count":1},{"year":2020,"count":2},{"year":2022,"count":1},{"year":2024,"count":1},{"year":2025,"count":2}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://www.tandfonline.com/doi/pdf/10.1080/14756360701654894?needAccess=true","host_type":"journal"},{"url":"https://www.tandfonline.com/doi/pdf/10.1080/14756360701654894?needAccess=true","host_type":"publisher"},{"url":"https://www.tandfonline.com/doi/pdf/10.1080/14756360701654894","host_type":"publisher"},{"url":"https://doi.org/10.1080/14756360701654894","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/18666000","host_type":"repository"},{"url":"https://doi.org/10.7270/q29885mb","host_type":"repository"}],"fields_of_study":["melanin and skin pigmentation","Biochemical Analysis and Sensing Techniques"],"mesh_terms":["alpha-MSH","Animals","Benzyl Alcohols","Kinetics","Melanocytes","Skin Pigmentation","Keratinocytes","Coculture Techniques","Cell Culture Techniques","Mice"],"keywords":["Melanocyte","Melanin","Keratinocyte","Tyrosinase","Cell culture","Cell biology","Biology","Microphthalmia-associated transcription factor","Cytotoxicity","Melanocyte-stimulating hormone","Endocrinology","In vitro","Biochemistry","Cancer research","Melanoma","Enzyme","Genetics","Receptor"],"sdg_mappings":[],"linked_datasets":[{"doi":"10.7270/q29885mb","title":"BindingDB Entry 5548: Effects of hydroxybenzyl alcohols on melanogenesis in melanocyte-keratinocyte co-culture and monolayer culture of melanocytes.","publisher":"BindingDB","resource_type":"Dataset"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T14:29:59.533804Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}