{"doi":"10.1080/1354750x.2025.2461069","title":"Differences in biomarkers of potential harm after 2+ years of tobacco heating system use compared to cigarette smoking: a cross-sectional study","abstract":null,"journal":"Biomarkers","year":2025,"id":635769,"datarank":0.32958368660043297,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.0,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1649581,"name":"Patrice Leroy","orcid":"0000-0001-8587-9517","position":1,"is_corresponding":false},{"id":1649582,"name":"Guillaume de La Bourdonnaye","orcid":"0000-0002-3412-0188","position":2,"is_corresponding":false},{"id":1649583,"name":"Sandrine Pouly","orcid":"0000-0001-9157-1252","position":3,"is_corresponding":false},{"id":1649584,"name":"Lindsay Reese","orcid":"0009-0000-4088-7118","position":4,"is_corresponding":false},{"id":1649585,"name":"Christelle Haziza","orcid":"0000-0002-4729-9252","position":5,"is_corresponding":false},{"id":1649580,"name":"S. Michael Ansari","orcid":"0000-0003-0947-7019","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Differences in biomarkers of potential harm after 2+ years of tobacco heating system use compared to cigarette smoking: a cross-sectional study","abstract":"Background Growing evidence indicates that noncombustible products could be a tobacco harm reduction tool for smokers who do not quit. The Tobacco Heating System (THS) emits substantially lower levels of harmful cigarette smoke constituents, and previous randomized clinical studies showed improved levels of biomarkers of potential harm (BoPH) linked to smoking-related disease.Methods In this cross-sectional study of healthy participants (n = 982) who (i) smoked cigarettes, (ii) had voluntarily switched from smoking to THS use, or (iii) formerly smoked, blood and urine samples were assayed for nine BoPH. The co-primary endpoints were carboxyhemoglobin, total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, white blood cells, and 8-epi-prostaglandin-F2α. The key secondary endpoints were high-density lipoprotein cholesterol, soluble intercellular adhesion molecule-1, 11-dehydrothromboxane B2, central vascular augmentation index, and forced expiratory volume in 1 s (%predicted post-bronchodilator).Results THS users showed significant favorable differences in all nine BoPH compared to current smokers. Results in THS users were similar to those in former smokers.Conclusion Compared to current smokers, healthy participants who voluntarily switched from smoking to THS use for ≥2 years in the real world had favorable differences in BoPH related to oxygen delivery, genotoxicity, inflammation, oxidative stress, lipid metabolism, endothelial function, platelet activation, and cardiovascular and respiratory function.Clinical trial registration: Clinicaltrials.gov Identifier: NCT05385055. Date of registration: May 23, 2022. https://clinicaltrials.gov/study/NCT05385055","is_dataset_classified":null,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39882959","pmcid":null,"openalex_id":"https://openalex.org/W4406988136","authors":[],"funders":[],"total_grants":0,"fwci":4.6932,"citation_percentile":0.94692163,"influential_citations":0,"citation_trend":[{"year":2025,"count":2},{"year":2026,"count":5}],"oa_status":"closed","license":"http://creativecommons.org/licenses/by-nc-nd/4.0/","oa_locations":[{"url":"https://www.tandfonline.com/doi/pdf/10.1080/1354750X.2025.2461069","host_type":"publisher"},{"url":"https://doi.org/10.1080/1354750x.2025.2461069","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39882959","host_type":"repository"}],"fields_of_study":["Smoking Behavior and Cessation","Alcohol Consumption and Health Effects","Heme Oxygenase-1 and Carbon Monoxide","Adult","Female","Humans","Male","Middle Aged","Biomarkers","Carboxyhemoglobin","Cholesterol, HDL","Cigarette Smoking","Cross-Sectional Studies","Dinoprost","Harm Reduction","Nitrosamines","Pyridines","Thromboxane B2","Tobacco Products","Hot Temperature"],"mesh_terms":["Cigarette Smoking","Adult","Carboxyhemoglobin","Cross-Sectional Studies","Female","Hot Temperature","Heating","Humans","Cholesterol, HDL","Male","Middle Aged","Nitrosamines","Pyridines","Thromboxane B2","Dinoprost","Biomarkers","Intercellular Adhesion Molecule-1","Harm Reduction","Tobacco Products"],"keywords":["Environmental health","Cross-sectional study","Cigarette smoking","Harm","Medicine","Tobacco use","Pathology","Internal medicine","Psychology","Population","Cardiovascular diseases","Inflammation","Respiratory function","Tobacco Harm Reduction","Tobacco Heating System","Biomarker Of Potential Harm"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"nct"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T15:32:02.911944Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}