{"doi":"10.1080/10715762.2022.2154667","title":"Association between lipid peroxidation and risk of type 2 diabetes in women","abstract":"In-vitro and animal studies demonstrate that lipid peroxidation plays an important role in the pathogenesis of type 2 diabetes (T2D). However, human data from prospective studies are limited and contradictory. We used data originally collected in two nested case-control studies of cancer to prospectively evaluate whether systemic levels of lipid peroxidation were associated with incidence of T2D in 1917 women who were 40–70 years old and diabetes-free at baseline. Lipid peroxidation was measured by urinary F2-isoprostanes (F2-IsoPs) and its major metabolite 2,3-dinor-5,6-dihydro-15-F2t-IsoP (F2-IsoP-M) with GC/NICI-MS assays. The Cox regression model was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for incident T2D. After a median follow-up of 10.1 years, 187 women were diagnosed with T2D. Urinary concentrations of both F2-IsoPs and F2-IsoP-M were significantly higher in T2D cases than in non-cases. Both biomarkers were positively associated with subsequent risk of T2D in multivariable-adjusted Cox models. When further adjusted for body mass index (BMI), the positive association with F2-IsoP-M was attenuated and no longer statistically significant, whereas the association with F2-IsoPs remained (P for overall significance < 0.001). HR for T2D was 1.68 (95% CI: 1.13, 2.51) for the highest vs the lowest quartile of F2-IsoPs. Moreover, this association appeared more pronounced among women with higher BMI. In summary, our study suggests that F2-IsoPs could be of significance in T2D risk prediction among middle-aged and elderly women.","journal":"Free Radical Research","year":2022,"id":313490,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9612,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":297595,"name":"Ginger L. Milne","orcid":"0000-0003-3890-151X","position":1,"is_corresponding":false},{"id":404612,"name":"Qingxia Chen","orcid":"0000-0003-0507-1847","position":2,"is_corresponding":false},{"id":45052,"name":"Qi Dai","orcid":"0000-0002-2082-0693","position":3,"is_corresponding":false},{"id":316735,"name":"Xianglan Zhang","orcid":"0000-0001-5653-5969","position":4,"is_corresponding":false},{"id":943157,"name":"Marina Sayuri Nogueira","orcid":"0000-0001-8092-928X","position":5,"is_corresponding":false},{"id":38542,"name":"Hui Cai","orcid":"0000-0002-2388-1694","position":6,"is_corresponding":false},{"id":340014,"name":"Qing Lan","orcid":"0000-0002-0888-8839","position":7,"is_corresponding":false},{"id":96418,"name":"Nathaniel Rothman","orcid":"0000-0001-6924-0895","position":8,"is_corresponding":false},{"id":86849,"name":"Qiuyin Cai","orcid":"0000-0002-9384-5648","position":9,"is_corresponding":false},{"id":291446,"name":"Yu‐Tang Gao","orcid":"0000-0003-3904-1777","position":10,"is_corresponding":false},{"id":240065,"name":"Xiao‐Ou Shu","orcid":"0000-0002-0711-8314","position":11,"is_corresponding":false},{"id":39347,"name":"Wei Zheng","orcid":"0000-0003-1226-070X","position":12,"is_corresponding":false},{"id":369712,"name":"Gong Yang","orcid":"0000-0002-7006-5825","position":13,"is_corresponding":false},{"id":748990,"name":"Yingya Zhao","orcid":null,"position":0,"is_corresponding":true}],"reference_count":33,"raw_metadata":null,"created_at":"2026-07-19T00:33:44.454239Z","pmid":"36480242","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}