{"doi":"10.1080/10715760701468740","title":"Hemin-induced Erk1/2 activation and heme oxygenase-1 expression in human umbilical vein endothelial cells","abstract":null,"journal":"Free Radical Research","year":2007,"id":657641,"datarank":0.4780418328273468,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.18615531046904976,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.18615531046904976,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":4,"citers_with_citation_signal":4,"citers_with_endowment":4,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":372329,"name":"Wei Shao","orcid":"0000-0003-1763-9911","position":1,"is_corresponding":false},{"id":1716747,"name":"Pingping Lv","orcid":null,"position":2,"is_corresponding":false},{"id":1716748,"name":"Shuluo Zhang","orcid":null,"position":3,"is_corresponding":false},{"id":1232485,"name":"Yingying Chen","orcid":"0000-0003-1669-8477","position":4,"is_corresponding":false},{"id":868877,"name":"Li Zhu","orcid":"0000-0002-6804-5235","position":5,"is_corresponding":false},{"id":425636,"name":"Yuan Lu","orcid":"0009-0003-6686-5584","position":6,"is_corresponding":false},{"id":1716749,"name":"Yueliang Shen","orcid":null,"position":7,"is_corresponding":false},{"id":1497275,"name":"Nan Chen","orcid":"0000-0001-6851-5658","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Hemin-induced Erk1/2 activation and heme oxygenase-1 expression in human umbilical vein endothelial cells","abstract":"Hemin has been reported to be protective in the pathological process, but its protective mechanisms have not been precisely defined. Hemin could induce Erk1/2 phosphorylation in astrocyte. Erk1/2 phosphorylation has been proved to be involved in many growth signals cellular transduction. However, little study has been conducted as to the relationship between hemin and Erk1/2 activation in human umbilical vein endothelial cells (HUVECs). The present study aimed to investigate the relationship between hemin and Erk1/2 phosphorylation in HUVECs. The results showed that low concentration of hemin induced and sustained phosphorylation of Erk1/2 for a long time. The HO inhibitor protoporphyrin IX zinc (II) abrogated phosphorylation of Erk1/2 induced by hemin. Biliverdin, one of the metabolites of hemin, obviously induced the Erk1/2 phosphorylation in HUVECs. Both hemin and biliverdin promoted HUVEC cell growth. The results strongly suggested that hemin could induce and sustain Erk1/2 phosphorylation in HUVECs by way of HO-1 induction and biliverdin produced from HO-1 catalysing hemin degradation.","is_dataset_classified":null,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"17729116","pmcid":null,"openalex_id":"https://openalex.org/W2118741710","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.1187703,"influential_citations":0,"citation_trend":[{"year":2014,"count":2},{"year":2015,"count":1},{"year":2017,"count":1},{"year":2018,"count":1},{"year":2021,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://www.tandfonline.com/doi/pdf/10.1080/10715760701468740","host_type":"publisher"},{"url":"https://doi.org/10.1080/10715760701468740","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/17729116","host_type":"repository"}],"fields_of_study":["Heme Oxygenase-1 and Carbon Monoxide","Neonatal Health and Biochemistry","Hemoglobin structure and function"],"mesh_terms":["Antioxidants","Cells, Cultured","Endothelium, Vascular","Hemin","Humans","Phosphorylation","Umbilical Veins","Mitogen-Activated Protein Kinase 1","Mitogen-Activated Protein Kinase 3","Heme Oxygenase-1"],"keywords":["Hemin","Umbilical vein","Biliverdin","Phosphorylation","Heme oxygenase","Heme","Chemistry","Biochemistry","Cell biology","Biology","Molecular biology","Enzyme","In vitro"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T01:51:12.244326Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}