{"doi":"10.1080/10428194.2017.1370547","title":"MYC immunohistochemical and cytogenetic analysis are required for identification of clinically relevant aggressive B cell lymphoma subtypes","abstract":null,"journal":"Leukemia &amp; Lymphoma","year":2018,"id":672824,"datarank":0.3958585994422889,"base_score":2.639057329615259,"endowment":2.639057329615259,"self_citation_contribution":0.3958585994422889,"citation_network_contribution":0.0,"self_endowment_contribution":0.3958585994422889,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1757974,"name":"Stephen R. Moore","orcid":null,"position":1,"is_corresponding":false},{"id":1757975,"name":"Michael J. Cascio","orcid":null,"position":2,"is_corresponding":false},{"id":783003,"name":"Jennifer Dunlap","orcid":"0000-0002-6399-6592","position":3,"is_corresponding":false},{"id":280221,"name":"Guang Fan","orcid":null,"position":4,"is_corresponding":false},{"id":1757976,"name":"Ken Gatter","orcid":null,"position":5,"is_corresponding":false},{"id":1290776,"name":"Susan B. Olson","orcid":"0000-0002-2564-3059","position":6,"is_corresponding":false},{"id":645445,"name":"Rita M. Braziel","orcid":null,"position":7,"is_corresponding":false},{"id":783004,"name":"Philipp W. Raess","orcid":"0000-0002-6841-4993","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"MYC immunohistochemical and cytogenetic analysis are required for identification of clinically relevant aggressive B cell lymphoma subtypes","abstract":"Accurate subclassification of aggressive B cell lymphomas (ABCLs) requires integration of morphologic, immunohistochemical (IHC), and cytogenetic information. Optimal strategies have not been well defined for diagnosis of high grade B cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements (HGBLwR) and double expressor lymphomas with MYC and BCL2 protein overexpression. One hundred and eighty seven ABCLs were investigated with complete IHC and FISH analysis. Morphologic and IHC analysis was insufficient to identify clinically relevant HGBLwR. Approximately, 75% of cases classified as HGBLwR showed conventional DLBCL morphologic features. Fourteen percent of MYC-rearranged cases were negative by IHC. Conversely, 60% of cases positive for MYC by IHC did not demonstrate a MYC rearrangement. Analysis by FISH without MYC and BCL2 IHC would miss 41 cases of double expressor lymphoma. Complete IHC and FISH analysis is recommended in the evaluation of all ABCLs.","is_dataset_classified":null,"base_score":2.639057329615259,"endowment":2.639057329615259,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28868942","pmcid":null,"openalex_id":"https://openalex.org/W2751509287","authors":[],"funders":[],"total_grants":0,"fwci":1.376,"citation_percentile":0.8006773,"influential_citations":0,"citation_trend":[{"year":2018,"count":2},{"year":2019,"count":4},{"year":2020,"count":2},{"year":2022,"count":1},{"year":2023,"count":1},{"year":2024,"count":1},{"year":2025,"count":1},{"year":2026,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.tandfonline.com/doi/pdf/10.1080/10428194.2017.1370547","host_type":"publisher"},{"url":"https://doi.org/10.1080/10428194.2017.1370547","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28868942","host_type":"repository"}],"fields_of_study":["Lymphoma Diagnosis and Treatment","Chronic Lymphocytic Leukemia Research","CAR-T cell therapy research","Biomarkers, Tumor","Cytogenetic Analysis","Gene Expression","Genetic Variation","Humans","Immunohistochemistry","In Situ Hybridization, Fluorescence","Ki-67 Antigen","Lymphoma, B-Cell","Neoplasm Grading","Neoplasm Staging","Proto-Oncogene Proteins c-myc","Reproducibility of Results"],"mesh_terms":["Humans","Immunohistochemistry","Neoplasm Staging","Biomarkers, Tumor","Genetic Variation","Reproducibility of Results","Gene Expression","Proto-Oncogene Proteins c-myc","Lymphoma, B-Cell","In Situ Hybridization, Fluorescence","Ki-67 Antigen","Cytogenetic Analysis","Neoplasm Grading"],"keywords":["Immunohistochemistry","BCL6","Lymphoma","Fish <Actinopterygii>","Pathology","Aggressive lymphoma","Medicine","Biology","Cancer research","B cell","Antibody","Immunology","Rituximab","Morphology","Cytogenetics","Molecular genetics","Lymphoma And Hodgkin Disease"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life below water"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-16T11:11:03.724163Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}