{"doi":"10.1080/09540121.2022.2052260","title":"Two or more significant life-events in 6-months are associated with lower rates of HIV treatment and virologic suppression among youth with HIV in Uganda and Kenya","abstract":"Youth living with HIV in sub-Saharan Africa have poor HIV care outcomes. We determined the association of recent significant life-events with HIV antiretroviral treatment (ART) initiation and HIV viral suppression in youth aged 15–24 years living with HIV in rural Kenya and Uganda. This was a cross-sectional analysis of 995 youth enrolled in the SEARCH Youth study. At baseline, providers assessed recent (within 6 months) life-events, defined as changes in schooling/employment, residence, partnerships, sickness, incarceration status, family strife or death, and birth/pregnancy, self-reported alcohol use, being a parent, and HIV-status disclosure. We examined the frequencies of events and their association with ART status and HIV viral suppression (<400 copies/ul). Recent significant life-events were prevalent (57.7%). Having >2 significant life-events (aOR = 0.61, 95% CI:0.45-0.85) and consuming alcohol (aOR = 0.61, 95% CI:0.43-0.87) were associated with a lower odds of HIV viral suppression, while disclosure of HIV-status to partner (aOR = 2.39, 95% CI:1.6-3.5) or to family (aOR = 1.86, 95% CI:1.3-2.7), being a parent (aOR = 1.8, 95% CI:1.2-2.5), and being single (aOR = 1.6, 95% CI:1.3-2.1) had a higher odds. This suggest that two or more recent life-events and alcohol use are key barriers to ART initiation and achievement of viral suppression among youth living with HIV in rural East Africa.Trial registration: ClinicalTrials.gov identifier: NCT03848728..","journal":"AIDS Care","year":2022,"id":265052,"datarank":0.42770366450445474,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.05496766703625462,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.05496766703625462,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":3,"citers_with_citation_signal":2,"citers_with_endowment":2,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9547,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT03848728"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":255274,"name":"Edwin D. Charlebois","orcid":"0000-0001-7237-2119","position":1,"is_corresponding":false},{"id":255275,"name":"James Ayieko","orcid":"0000-0002-0324-4006","position":2,"is_corresponding":false},{"id":924210,"name":"Winter Olio","orcid":null,"position":3,"is_corresponding":false},{"id":257121,"name":"Douglas Black","orcid":null,"position":4,"is_corresponding":false},{"id":255281,"name":"James Peng","orcid":"0000-0002-8245-8319","position":5,"is_corresponding":false},{"id":255276,"name":"Dalsone Kwarisiima","orcid":"0000-0003-2886-9261","position":6,"is_corresponding":false},{"id":255277,"name":"Jane Kabami","orcid":"0000-0002-0265-3174","position":7,"is_corresponding":false},{"id":255278,"name":"Laura B. Balzer","orcid":"0000-0002-3730-410X","position":8,"is_corresponding":false},{"id":255295,"name":"Maya L. Petersen","orcid":"0000-0002-5505-153X","position":9,"is_corresponding":false},{"id":324168,"name":"Bill G. Kapogiannis","orcid":"0000-0003-0754-9090","position":10,"is_corresponding":false},{"id":242453,"name":"Moses R. Kamya","orcid":"0000-0001-9106-4234","position":11,"is_corresponding":false},{"id":58746,"name":"Diane V. Havlir","orcid":"0000-0003-0761-3136","position":12,"is_corresponding":false},{"id":255289,"name":"Theodore Ruel","orcid":"0000-0002-1105-9126","position":13,"is_corresponding":false},{"id":255280,"name":"Florence Mwangwa","orcid":"0000-0001-9467-0950","position":0,"is_corresponding":true}],"reference_count":44,"raw_metadata":null,"created_at":"2026-07-19T00:26:45.905331Z","pmid":"35578398","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}