{"doi":"10.1080/07391102.2018.1436089","title":"Matrix proteins of enveloped viruses: a case study of Influenza A virus M1 protein","abstract":null,"journal":"Journal of Biomolecular Structure and Dynamics","year":2019,"id":645422,"datarank":0.5570358100056463,"base_score":3.713572066704308,"endowment":3.713572066704308,"self_citation_contribution":0.5570358100056463,"citation_network_contribution":0.0,"self_endowment_contribution":0.5570358100056463,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":40,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1680590,"name":"Eleonora V. Shtykova","orcid":null,"position":1,"is_corresponding":false},{"id":1680591,"name":"Lyudmila A. Baratova","orcid":null,"position":2,"is_corresponding":false},{"id":257884,"name":"Dmitri I. Svergun","orcid":"0000-0003-0830-5696","position":3,"is_corresponding":false},{"id":1252573,"name":"Oleg V. Batishchev","orcid":"0000-0002-9581-2233","position":4,"is_corresponding":false},{"id":1680589,"name":"Larisa V. Kordyukova","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Matrix proteins of enveloped viruses: a case study of Influenza A virus M1 protein","abstract":"Influenza A virus, a member of the Orthomyxoviridae family of enveloped viruses, is one of the human and animal top killers, and its structure and components are therefore extensively studied during the last decades. The most abundant component, M1 matrix protein, forms a matrix layer (scaffold) under the viral lipid envelope, and the functional roles as well as structural peculiarities of the M1 protein are still under heavy debate. Despite multiple attempts of crystallization, no high resolution structure is available for the full length M1 of Influenza A virus. The likely reason for the difficulties lies in the intrinsic disorder of the M1 C-terminal part preventing diffraction quality crystals to be grown. Alternative structural methods including synchrotron small-angle X-ray scattering (SAXS), atomic force microscopy, cryo-electron microscopy/tomography are therefore widely applied to understand the structure of M1, its self-association and interactions with the lipid membrane and the viral nucleocapsid. These methods reveal striking similarities in the behavior of M1 and matrix proteins of other enveloped RNA viruses, with the differences accompanied by the specific features of the viral lifecycles, thus suggesting common interaction principles and, possibly, common evolutional ancestors. The structural information on the Influenza A virus M1 protein obtained to the date strongly suggests that the intrinsic disorder in the C-terminal domain has important functional implications.","is_dataset_classified":null,"base_score":3.713572066704308,"endowment":3.713572066704308,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"29388479","pmcid":null,"openalex_id":"https://openalex.org/W2789523019","authors":[],"funders":[{"funder_name":"Russian Foundation for Basic Research","grant_id":"15-04-05044","title":null},{"funder_name":"Russian Foundation for Basic Research","grant_id":"15-54-74002","title":null},{"funder_name":"Russian Foundation for Basic Research","grant_id":"17-54-30022","title":null},{"funder_name":"Russian Foundation for Basic Research","grant_id":"16-04-00563","title":null},{"funder_name":"Russian Foundation for Basic Research","grant_id":"#15–04-05044","title":null},{"funder_name":"Russian Foundation for Basic Research","grant_id":"#16–04-00563","title":null},{"funder_name":"Russian Foundation for Basic Research","grant_id":"#17–54-30022","title":null},{"funder_name":"Russian Foundation for Basic Research","grant_id":"#15–54-74002","title":null}],"total_grants":8,"fwci":3.1553,"citation_percentile":0.92188169,"influential_citations":0,"citation_trend":[{"year":2018,"count":3},{"year":2019,"count":4},{"year":2020,"count":10},{"year":2021,"count":4},{"year":2022,"count":2},{"year":2023,"count":10},{"year":2024,"count":2},{"year":2025,"count":2},{"year":2026,"count":3}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.tandfonline.com/doi/pdf/10.1080/07391102.2018.1436089","host_type":"publisher"},{"url":"https://doi.org/10.1080/07391102.2018.1436089","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/29388479","host_type":"repository"}],"fields_of_study":["Influenza Virus Research Studies","Bacteriophages and microbial interactions","Respiratory viral infections research","Antiviral Agents","Influenza A virus","Protein Binding","Protein Multimerization","Viral Matrix Proteins","Virion"],"mesh_terms":["Antiviral Agents","Influenza A virus","Protein Binding","Viral Matrix Proteins","Virion","Protein Multimerization"],"keywords":["Viral matrix protein","Viral envelope","Virus","Small-angle X-ray scattering","Viral protein","Biology","Cryo-electron microscopy","Virology","Protein structure","Influenza A virus","Protein domain","Chemistry","Biophysics","Computational biology","Gene","Genetics","Physics","Scattering","Biochemistry","Intrinsically Disordered Proteins","Enveloped Viruses","M1 Matrix Protein","M1 Self-association","Matrix Scaffold","M1–lipid Interactions"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T05:30:27.466565Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}