{"doi":"10.1076/ceyr.24.1.26.5432","title":"Ganglion cell responses to retinal light stimulation in the absence of photoreceptor outer segments from retinal degenerate rodents","abstract":null,"journal":"Current Eye Research","year":2002,"id":675738,"datarank":1.673434701693474,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"self_citation_contribution":0.44166584687496613,"citation_network_contribution":1.231768854818508,"self_endowment_contribution":0.44166584687496613,"citer_contribution":1.231768854818508,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":13,"citers_with_citation_signal":13,"citers_with_endowment":13,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1765591,"name":"Nobuya Asayama","orcid":null,"position":1,"is_corresponding":false},{"id":339553,"name":"Mark S. Humayun","orcid":"0000-0002-5830-5208","position":2,"is_corresponding":false},{"id":1765592,"name":"James Weiland","orcid":null,"position":3,"is_corresponding":false},{"id":1765593,"name":"Jingtai Cao","orcid":null,"position":4,"is_corresponding":false},{"id":1765594,"name":"Shang-Yeon Kim","orcid":null,"position":5,"is_corresponding":false},{"id":1765595,"name":"Rhonda R. Grebe","orcid":null,"position":6,"is_corresponding":false},{"id":1734356,"name":"Eugene de Juan","orcid":null,"position":7,"is_corresponding":false},{"id":263805,"name":"Srinivas R. Sadda","orcid":"0000-0002-4939-3306","position":8,"is_corresponding":false},{"id":1765589,"name":"Gi-Jung An","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Ganglion cell responses to retinal light stimulation in the absence of photoreceptor outer segments from retinal degenerate rodents","abstract":"PURPOSE: To determine whether a severely degenerated retina without photoreceptor outer segments and a non-recordable electroretinogram (ERG) can still show retinal ganglion cell (RGC) responses to retinal light stimulation. METHODS: The authors measured ERGs and retinal surface RGC responses from six week old rd mice and three month old homozygous S334ter line3 rats. Animal eyes were also studied by light microscopy, transmission electron microscopy, and immunohistochemistry (rats). RESULTS: The corneal ERGs were non-recordable and no photoreceptor outer segments were found in either retinal degeneration model. A few cell bodies (without outer segments) that were immunoreactive for cone opsin and rhodopsin were found in the outer nuclear layer of the rats. Light-driven ON-RGC responses, however, were recordable from six week old rd mice. In addition, light-driven ON and OFF-RGC responses were recordable from three month old homozygous S334ter line 3 rats. CONCLUSIONS: This study suggests that despite the apparent absence of photoreceptor outer segments and a non-recordable ERG, ganglion cell responses to retinal light stimulation may remain preserved in some severe retinal degenerate transgenic rodents.","is_dataset_classified":null,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"12187491","pmcid":null,"openalex_id":"https://openalex.org/W2089767180","authors":[],"funders":[],"total_grants":0,"fwci":0.438,"citation_percentile":0.60581065,"influential_citations":0,"citation_trend":[{"year":2012,"count":2},{"year":2014,"count":1},{"year":2017,"count":2},{"year":2018,"count":1},{"year":2023,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://www.tandfonline.com/doi/pdf/10.1076/ceyr.24.1.26.5432","host_type":"publisher"},{"url":"https://doi.org/10.1076/ceyr.24.1.26.5432","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/12187491","host_type":"repository"}],"fields_of_study":["Retinal Development and Disorders","Photoreceptor and optogenetics research","Circadian rhythm and melatonin"],"mesh_terms":["Animals","Animals, Newborn","Electroretinography","Immunoenzyme Techniques","Mice, Inbred C3H","Mice, Inbred C57BL","Photic Stimulation","Retina","Retinal Degeneration","Retinal Ganglion Cells","Rod Cell Outer Segment","Rats, Sprague-Dawley","Mice","Rats"],"keywords":["Retina","Retinal","Photoreceptor cell","Biology","Opsin","Retinal degeneration","Outer nuclear layer","Rhodopsin","Ganglion","Anatomy","Electroretinography","Retinal ganglion cell","Intrinsically photosensitive retinal ganglion cells","Giant retinal ganglion cells","Erg","Ganglion cell layer","Neuroscience"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T01:38:17.385470Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}