{"doi":"10.1074/jbc.ra120.015515","title":"The human mitochondrial enzyme BCO2 exhibits catalytic activity toward carotenoids and apocarotenoids","abstract":"did not impede the chimeric enzyme's catalytic proficiency. We further showed that the chimeric BCO2 displayed broad substrate specificity and converted carotenoids into two ionones and a central C14-apocarotendial by oxidative cleavage reactions at C9,C10 and C9',C10'. Thus, our study demonstrates that human BCO2 is a catalytically competent enzyme. Consequently, information on BCO2 becomes broadly applicable in human biology with important implications for the physiology of the eyes and other tissues.","journal":"Journal of Biological Chemistry","year":2020,"id":94389,"datarank":1.0640191532983543,"base_score":3.6635616461296463,"endowment":3.6635616461296463,"self_citation_contribution":0.5495342469194471,"citation_network_contribution":0.5144849063789072,"self_endowment_contribution":0.5495342469194471,"citer_contribution":0.5144849063789072,"corpus_percentile":null,"corpus_rank":null,"citation_count":38,"citer_count":24,"citers_with_citation_signal":22,"citers_with_endowment":22,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9588,"is_data_producer":true,"deposit_databanks":{"PDB":["6VCH"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":417587,"name":"Sepalika Bandara","orcid":"0000-0003-1029-1457","position":1,"is_corresponding":false},{"id":470139,"name":"Vipul M. Parmar","orcid":"0000-0001-6696-357X","position":2,"is_corresponding":false},{"id":315236,"name":"Srinivasagan Ramkumar","orcid":"0000-0002-2542-1501","position":3,"is_corresponding":false},{"id":470753,"name":"Nimesh Khadka","orcid":null,"position":4,"is_corresponding":false},{"id":337166,"name":"Marcin Golczak","orcid":"0000-0001-7477-4357","position":5,"is_corresponding":false},{"id":254242,"name":"Philip D. Kiser","orcid":"0000-0003-1184-9539","position":6,"is_corresponding":false},{"id":315246,"name":"Johannes von Lintig","orcid":"0000-0002-2079-2143","position":7,"is_corresponding":false},{"id":470138,"name":"Linda D. Thomas","orcid":"0000-0003-0063-4516","position":0,"is_corresponding":true}],"reference_count":69,"raw_metadata":null,"created_at":"2026-07-18T22:32:04.778261Z","pmid":"32873706","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}