{"doi":"10.1074/jbc.ra120.014903","title":"The ATPase mechanism of myosin 15, the molecular motor mutated in DFNB3 human deafness","abstract":"at 20 °C), although this did not rate-limit the ATPase cycle. The kinetic analysis shows the MYO15 motor domain has a moderate duty ratio (∼0.5) and weak thermodynamic coupling between ADP and actin binding. These findings are consistent with MYO15 being kinetically adapted for processive motility when oligomerized. Our kinetic characterization enables future studies into how deafness-causing mutations affect MYO15 and disrupt stereocilia trafficking necessary for hearing.","journal":"Journal of Biological Chemistry","year":2020,"id":79130,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.961,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":306272,"name":"Yasuharu Takagi","orcid":null,"position":1,"is_corresponding":false},{"id":411444,"name":"Arik Shams","orcid":"0000-0002-0151-0593","position":2,"is_corresponding":false},{"id":411445,"name":"Sarah M. Heissler","orcid":"0000-0002-6972-7940","position":3,"is_corresponding":false},{"id":70685,"name":"Thomas B. Friedman","orcid":"0000-0003-4614-6630","position":4,"is_corresponding":false},{"id":320691,"name":"James R. Sellers","orcid":"0000-0001-6296-564X","position":5,"is_corresponding":false},{"id":304021,"name":"Jonathan E. Bird","orcid":"0000-0001-5531-8794","position":6,"is_corresponding":false},{"id":412611,"name":"Fangfang Jiang","orcid":null,"position":0,"is_corresponding":true}],"reference_count":106,"raw_metadata":null,"created_at":"2026-07-18T21:50:33.748601Z","pmid":"33372036","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}