{"doi":"10.1074/jbc.ra120.014889","title":"A clinically relevant polymorphism in the Na+/taurocholate cotransporting polypeptide (NTCP) occurs at a rheostat position","abstract":"/TCA cotransporting polypeptide structure model. Across the modest range of changes, calculated stabilities correlated with surface-expression differences, but neither parameter correlated with altered transport. Thus, substitutions at rheostat position 267 had wide-ranging effects on the phenotype of this integral membrane protein. We further propose that polymorphic positions in other proteins might be locations of rheostat positions.","journal":"Journal of Biological Chemistry","year":2020,"id":98801,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":31,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9565,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":486940,"name":"Shipra Malhotra","orcid":"0000-0002-2234-191X","position":1,"is_corresponding":false},{"id":396837,"name":"Aron W. Fenton","orcid":"0000-0001-8214-4785","position":2,"is_corresponding":false},{"id":396836,"name":"Liskin Swint‐Kruse","orcid":"0000-0002-5925-9741","position":3,"is_corresponding":false},{"id":259373,"name":"John Karanicolas","orcid":"0000-0003-0300-726X","position":4,"is_corresponding":false},{"id":448660,"name":"Bruno Hagenbuch","orcid":"0000-0002-2938-8630","position":5,"is_corresponding":false},{"id":449970,"name":"Melissa Ruggiero","orcid":null,"position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":null,"created_at":"2026-07-18T22:36:58.511143Z","pmid":"33168628","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}