{"doi":"10.1074/jbc.ra120.013530","title":"Novel role of ASH1L histone methyltransferase in anaplastic thyroid carcinoma","abstract":"WT ATC cell lines revealed that ASH1L is involved in the regulation of numerous cancer-related genes and gene sets. The pro-oncogenic long noncoding RNA colon cancer-associated transcript 1 (CCAT1) was one of the most highly (approximately 68-fold) down-regulated transcripts in ASH1L knockout cells. Therefore, we investigated CCAT1 as a potential mediator of the growth-inducing activity of ASH1L. Supporting this hypothesis, CCAT1 knockdown in ATC cells decreased their growth rate, and ChIP-Seq data indicated that CCAT1 is likely a direct target of ASH1L's histone methyltransferase activity. These results indicate that ASH1L contributes to the aggressiveness of ATC and suggest that ASH1L, along with its upstream regulator miR-200b-3p and its downstream mediator CCAT1, represents a potential therapeutic target in ATC.","journal":"Journal of Biological Chemistry","year":2020,"id":93282,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":40,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9609,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":418024,"name":"Tingting Qin","orcid":"0000-0003-3810-7578","position":1,"is_corresponding":false},{"id":465870,"name":"Jingcheng Yu","orcid":"0000-0003-0222-5046","position":2,"is_corresponding":false},{"id":70160,"name":"Thomas J. Giordano","orcid":"0000-0003-0641-8873","position":3,"is_corresponding":false},{"id":363234,"name":"Maureen A. Sartor","orcid":"0000-0001-6155-5702","position":4,"is_corresponding":false},{"id":465871,"name":"Ronald J. Koenig","orcid":"0000-0003-0021-4976","position":5,"is_corresponding":false},{"id":465869,"name":"Bin Xu","orcid":"0000-0002-5099-6673","position":0,"is_corresponding":true}],"reference_count":69,"raw_metadata":null,"created_at":"2026-07-18T22:30:54.208860Z","pmid":"32398261","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}