{"doi":"10.1074/jbc.ra120.012801","title":"AI26 inhibits the ADP-ribosylhydrolase ARH3 and suppresses DNA damage repair","abstract":"Moreover, hydrolysis of DNA damage-induced ADP-ribosylation was clearly inhibited when cells were pretreated with AI26, leading to defects in DNA damage repair. In addition, tumor cells with DNA damage repair defects were hypersensitive to AI26 treatment, as well as combinations of AI26 and other DNA-damaging agents such as camptothecin and doxorubicin. Collectively, these results reveal not only a chemical probe to study ARH3-mediated DNA damage repair but also a chemotherapeutic strategy for tumor suppression.","journal":"Journal of Biological Chemistry","year":2020,"id":81312,"datarank":0.7282524716716503,"base_score":2.70805020110221,"endowment":2.70805020110221,"self_citation_contribution":0.40620753016533157,"citation_network_contribution":0.3220449415063187,"self_endowment_contribution":0.40620753016533157,"citer_contribution":0.3220449415063187,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":13,"citers_with_citation_signal":12,"citers_with_endowment":12,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9549,"is_data_producer":true,"deposit_databanks":{"PDB":["5ZQY","6IUX","6LH4","4J5R"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":420552,"name":"Rong Xie","orcid":"0000-0002-8277-7280","position":1,"is_corresponding":false},{"id":421397,"name":"Lily Yu","orcid":null,"position":2,"is_corresponding":false},{"id":352807,"name":"Shih-Hsun Chen","orcid":"0000-0002-5750-6470","position":3,"is_corresponding":false},{"id":420553,"name":"Xiaoyun Yang","orcid":"0000-0002-1374-2201","position":4,"is_corresponding":false},{"id":352808,"name":"Anup K. Singh","orcid":"0000-0001-5180-0727","position":5,"is_corresponding":false},{"id":420554,"name":"Hongzhi Li","orcid":"0000-0001-6457-6496","position":6,"is_corresponding":false},{"id":420555,"name":"Chen Wu","orcid":"0000-0003-3957-9454","position":7,"is_corresponding":false},{"id":332095,"name":"Xiaochun Yu","orcid":"0000-0001-9840-2670","position":8,"is_corresponding":false},{"id":332094,"name":"Xiuhua Liu","orcid":"0000-0001-9734-8772","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":null,"created_at":"2026-07-18T21:52:34.401799Z","pmid":"32753484","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}