{"doi":"10.1074/jbc.ra119.012377","title":"Chlorpromazine binding to the PAS domains uncovers the effect of ligand modulation on EAG channel activity","abstract":"channels and places the PAS domain as a new target for drug discovery in EAG and related channels. Up-regulation of EAG channel activity is linked to cancer and neurological disorders. Our study raises the possibility of repurposing the antipsychotic drug chlorpromazine for treatment of neurological disorders and cancer.","journal":"Journal of Biological Chemistry","year":2020,"id":96327,"datarank":0.848029453633841,"base_score":3.5553480614894135,"endowment":3.5553480614894135,"self_citation_contribution":0.5333022092234121,"citation_network_contribution":0.3147272444104289,"self_endowment_contribution":0.5333022092234121,"citer_contribution":0.3147272444104289,"corpus_percentile":null,"corpus_rank":null,"citation_count":34,"citer_count":27,"citers_with_citation_signal":16,"citers_with_endowment":16,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.959,"is_data_producer":true,"deposit_databanks":{"PDB":["5K7L","4HOI"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":477530,"name":"Stephanie M. Soohoo","orcid":"0000-0002-7334-9807","position":1,"is_corresponding":false},{"id":397586,"name":"Purushottam B. Tiwari","orcid":"0000-0002-3140-0723","position":2,"is_corresponding":false},{"id":313757,"name":"Grzegorz Piszczek","orcid":"0000-0002-5270-3678","position":3,"is_corresponding":false},{"id":477531,"name":"Tinatin I. Brelidze","orcid":"0000-0003-3046-8184","position":4,"is_corresponding":false},{"id":237998,"name":"Zejun Wang","orcid":"0000-0003-0313-5819","position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":null,"created_at":"2026-07-18T22:34:34.781847Z","pmid":"32047112","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}