{"doi":"10.1074/jbc.m706968200","title":"Translational Efficiency of a Non-AUG Initiation Codon Is Significantly Affected by Its Sequence Context in Yeast","abstract":null,"journal":"Journal of Biological Chemistry","year":2008,"id":659760,"datarank":0.6090664515819629,"base_score":4.060443010546419,"endowment":4.060443010546419,"self_citation_contribution":0.6090664515819629,"citation_network_contribution":0.0,"self_endowment_contribution":0.6090664515819629,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":57,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":391140,"name":"Grace Lin","orcid":"0000-0001-8018-5604","position":1,"is_corresponding":false},{"id":1722241,"name":"Kuang-Jung Chang","orcid":null,"position":2,"is_corresponding":false},{"id":1722242,"name":"Lu-Shu Yeh","orcid":null,"position":3,"is_corresponding":false},{"id":1722243,"name":"Chien-Chia Wang","orcid":null,"position":4,"is_corresponding":false},{"id":1722240,"name":"Shun-Jia Chen","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Translational Efficiency of a Non-AUG Initiation Codon Is Significantly Affected by Its Sequence Context in Yeast","abstract":"Previous studies have shown that translation of mrna for yeast glycyl-tRNA synthetase is alternatively initiated from UUG and a downstream AUG initiation codon. Evidence presented here shows that unlike an AUG initiation codon, efficiency of this non-AUG initiation codon is significantly affected by its sequence context, in particular the nucleotides at positions -3 to -1 relative to the initiation codon. A/A/R (R represents A Or G) and C/G/C appear to be the most and least favorable sequences at these positions, respectively. Mutation of the native context sequence -3 to -1 from AAA to CGC reduced translation initiation from the UUG codon up to 32-fold and resulted in loss of mitochondrial respiration. although an AUG initiation codon is, in general, unresponsive to context changes in yeast, an AAA (-3 to -1) to CGC mutation still reduced its initiating activity up to 8-fold under similar conditions. these results suggest that sequence context is more important for translation initiation in yeast than previously appreciated.","is_dataset_classified":null,"base_score":4.060443010546419,"endowment":4.060443010546419,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18065417","pmcid":null,"openalex_id":"https://openalex.org/W2063795380","authors":[],"funders":[],"total_grants":0,"fwci":0.5032,"citation_percentile":0.63548299,"influential_citations":0,"citation_trend":[{"year":2012,"count":3},{"year":2013,"count":5},{"year":2014,"count":3},{"year":2015,"count":5},{"year":2016,"count":3},{"year":2017,"count":4},{"year":2018,"count":1},{"year":2019,"count":6},{"year":2020,"count":5},{"year":2021,"count":2},{"year":2022,"count":1},{"year":2023,"count":2},{"year":2024,"count":3},{"year":2025,"count":1}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1074/jbc.m706968200","host_type":"journal"},{"url":"https://doi.org/10.1074/jbc.m706968200","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0021925820697794?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0021925820697794?httpAccept=text/plain","host_type":"publisher"},{"url":"https://syndication.highwire.org/content/doi/10.1074/jbc.M706968200","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/18065417","host_type":"repository"},{"url":"http://www.jbc.org/content/283/6/3173.full.pdf","host_type":"Unpaywall"}],"fields_of_study":["RNA and protein synthesis mechanisms","RNA modifications and cancer","RNA Research and Splicing","Base Sequence","Codon","Codon, Initiator","Gene Expression Regulation, Fungal","Genetic Complementation Test","Mitochondria","Models, Genetic","Molecular Sequence Data","Mutation","Peptide Chain Initiation, Translational","Plasmids","Protein Biosynthesis","Ribosomes","Saccharomyces cerevisiae"],"mesh_terms":["Base Sequence","Codon","Genetic Complementation Test","Mitochondria","Models, Genetic","Molecular Sequence Data","Mutation","Peptide Chain Initiation, Translational","Plasmids","Ribosomes","Saccharomyces cerevisiae","Protein Biosynthesis","Gene Expression Regulation, Fungal","Codon, Initiator"],"keywords":["Start codon","Eukaryotic translation","Transfer RNA","Biology","Genetics","Context (archaeology)","Five prime untranslated region","Translation (biology)","Stop codon","Silent mutation","Messenger RNA","Mutation","Gene","RNA"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T07:34:25.431854Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}