{"doi":"10.1074/jbc.m705401200","title":"BAF60a Interacts with p53 to Recruit the SWI/SNF Complex","abstract":null,"journal":"Journal of Biological Chemistry","year":2008,"id":592402,"datarank":4.5985131422362295,"base_score":4.605170185988092,"endowment":4.605170185988092,"self_citation_contribution":0.6907755278982138,"citation_network_contribution":3.907737614338016,"self_endowment_contribution":0.6907755278982138,"citer_contribution":3.907737614338016,"corpus_percentile":null,"corpus_rank":null,"citation_count":99,"citer_count":98,"citers_with_citation_signal":90,"citers_with_endowment":90,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1515851,"name":"Dong H. Sohn","orcid":null,"position":1,"is_corresponding":false},{"id":1069961,"name":"Myunggon Ko","orcid":"0000-0002-6007-2570","position":2,"is_corresponding":false},{"id":1515852,"name":"Heekyoung Chung","orcid":null,"position":3,"is_corresponding":false},{"id":1515853,"name":"Sung H. Jeon","orcid":null,"position":4,"is_corresponding":false},{"id":1515854,"name":"Rho H. Seong","orcid":null,"position":5,"is_corresponding":false},{"id":1515850,"name":"Jaehak Oh","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"BAF60a Interacts with p53 to Recruit the SWI/SNF Complex","abstract":"To understand the tumor-suppressing mechanism of the SWI/SNF chromatin remodeling complex, we investigated its molecular relationship with p53. Using the pREP4-luc episomal reporter, we first demonstrated that p53 utilizes the chromatin remodeling activity of the SWI/SNF complex to initiate transcription from the chromatin-structured promoter. Among the components of the SWI/SNF complex, we identified BAF60a as a mediator of the interaction with p53 by the yeast two-hybrid assay. p53 directly interacted only with BAF60a, but not with other components of the SWI/SNF complex, such as BRG1, SRG3, SNF5, or BAF57. We found out that multiple residues at the amino acid 108-150 region of BAF60a were involved in the interaction with the tetramerization domain of p53. The N-terminal fragment of BAF60a containing the p53-interacting region as well as small interfering RNA for baf60a inhibited the SWI/SNF complex-mediated transcriptional activity of p53. The uncoupling of p53 with the SWI/SNF complex resulted in the repression of both p53-dependent apoptosis and cell cycle arrest by the regulation of target genes. These results suggest that the SWI/SNF chromatin remodeling complex is involved in the suppression of tumors by the interaction with p53.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18303029","pmcid":null,"openalex_id":null,"authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":null,"license":"http://creativecommons.org/licenses/by/4.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0021925820492944?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0021925820492944?httpAccept=text/plain","host_type":"publisher"},{"url":"https://syndication.highwire.org/content/doi/10.1074/jbc.M705401200","host_type":"publisher"},{"url":"https://doi.org/10.1074/jbc.m705401200","host_type":"Unpaywall"}],"fields_of_study":[],"mesh_terms":["Cell Line","Animals","Humans","Mice","Doxorubicin","Chromosomal Proteins, Non-Histone","Transcription Factors","Transduction, Genetic","Protein Interaction Mapping","Cell Cycle","Apoptosis","Chromatin Assembly and Disassembly","Transcription, Genetic","Down-Regulation","Amino Acid Sequence","Protein Structure, Tertiary","Protein Binding","Tumor Suppressor Protein p53","Mutant Proteins"],"keywords":[],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-26T13:31:32.785108Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}