{"doi":"10.1074/jbc.m306621200","title":"Regulation of Platelet-derived Growth Factor-A Chain by Krüppel-like Factor 5","abstract":null,"journal":"Journal of Biological Chemistry","year":2004,"id":689928,"datarank":0.6830815337400812,"base_score":4.553876891600541,"endowment":4.553876891600541,"self_citation_contribution":0.6830815337400812,"citation_network_contribution":0.0,"self_endowment_contribution":0.6830815337400812,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":94,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1387551,"name":"Toru Suzuki","orcid":"0000-0002-8371-664X","position":1,"is_corresponding":false},{"id":1802402,"name":"Nanae Kada","orcid":null,"position":2,"is_corresponding":false},{"id":1802403,"name":"Atsushi Ishihara","orcid":null,"position":3,"is_corresponding":false},{"id":1591884,"name":"Keiko Kawai-Kowase","orcid":null,"position":4,"is_corresponding":false},{"id":1410655,"name":"Takayoshi Matsumura","orcid":"0000-0003-3394-9506","position":5,"is_corresponding":false},{"id":1802404,"name":"Kana Sasaki","orcid":null,"position":6,"is_corresponding":false},{"id":1802405,"name":"Yoshiko Munemasa","orcid":null,"position":7,"is_corresponding":false},{"id":1497230,"name":"Ichiro Manabe","orcid":"0000-0001-9481-6673","position":8,"is_corresponding":false},{"id":11195,"name":"Masahiko Kurabayashi","orcid":"0000-0002-9445-6759","position":9,"is_corresponding":false},{"id":1802406,"name":"Tucker Collins","orcid":null,"position":10,"is_corresponding":false},{"id":11202,"name":"Ryozo Nagai","orcid":"0000-0002-0911-7868","position":11,"is_corresponding":false},{"id":1802401,"name":"Kenichi Aizawa","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Regulation of Platelet-derived Growth Factor-A Chain by Krüppel-like Factor 5","abstract":"The transcription factor Krüppel-like factor 5 (KLF5) and its genetically downstream target gene platelet-derived growth factor-A (PDGF-A) chain are key factors in regulation of cardiovascular remodeling in response to stress. We show that KLF5 mediates a novel distinct delayed persistent induction of PDGF-A chain in response to the model agonist, phorbol ester, through a cis-element previously shown to mediate phorbol ester induction on to PDGF-A chain through the early growth response factor (Egr-1). Interestingly, the nuclear factor-kappaB (NF-kappaB) p50 subunit further cooperatively activates PDGF-A chain through protein-protein interaction with KLF5 but not Egr-1. RNA interference analysis confirmed that KLF5 and p50 are important for induction of PDGF-A chain. Collectively, we identify a novel regulatory pathway in which PDGF-A chain gene expression, under the control of KLF5, is cooperatively activated by the NF-kappaB p50 subunit and a pathophysiological stimulus.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"14573617","pmcid":null,"openalex_id":null,"authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1074/jbc.m306621200","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0021925818527897?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0021925818527897?httpAccept=text/plain","host_type":"publisher"},{"url":"https://syndication.highwire.org/content/doi/10.1074/jbc.M306621200","host_type":"publisher"}],"fields_of_study":[],"mesh_terms":["Hela Cells","Humans","Luciferases","Platelet-Derived Growth Factor","NF-kappa B","Trans-Activators","Protein Subunits","Recombinant Proteins","DNA Primers","Transfection","Binding Sites","Base Sequence","Zinc Fingers","Genes, Reporter","Kruppel-Like Transcription Factors","Promoter Regions, Genetic","Transcriptional Activation"],"keywords":[],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-22T18:50:07.507278Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}