{"doi":"10.1074/jbc.m210819200","title":"15d-PGJ2 and Rosiglitazone Suppress Janus Kinase-STAT Inflammatory Signaling through Induction of Suppressor of Cytokine Signaling 1 (SOCS1) and SOCS3 in Glia","abstract":null,"journal":"Journal of Biological Chemistry","year":2003,"id":656559,"datarank":0.8041938248564139,"base_score":5.3612921657094255,"endowment":5.3612921657094255,"self_citation_contribution":0.8041938248564139,"citation_network_contribution":0.0,"self_endowment_contribution":0.8041938248564139,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":212,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":951424,"name":"Soo Young Park","orcid":"0000-0002-2272-8524","position":1,"is_corresponding":false},{"id":1713878,"name":"Eun-hye Joe","orcid":null,"position":2,"is_corresponding":false},{"id":1713879,"name":"Ilo Jou","orcid":null,"position":3,"is_corresponding":false},{"id":687608,"name":"Eun Jung Park","orcid":"0000-0002-4559-2690","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"15d-PGJ2 and Rosiglitazone Suppress Janus Kinase-STAT Inflammatory Signaling through Induction of Suppressor of Cytokine Signaling 1 (SOCS1) and SOCS3 in Glia","abstract":"Peroxisome proliferator-activated receptor (PPAR)-gamma agonists are now emerging as therapeutic drugs for various inflammatory diseases. However, their molecular mechanism of action remains to be elucidated. Here we report a novel mechanism that underlies the PPAR-gamma agonist-mediated suppression of brain inflammation. We show that 15-deoxy-Delta12,14-prostaglandin J(2) (15d-PGJ(2)) and rosiglitazone reduce the phosphorylation of STAT1 and STAT3 as well as Janus kinase 1 (JAK1) and JAK2 in activated astrocytes and microglia. The PPAR-gamma agonist-mediated reduction in phosphorylation leads to the suppression of JAK-STAT-dependent inflammatory responses. The effects of 15d-PGJ(2) and rosiglitazone are not mediated by activation of PPAR-gamma. 15d-PGJ(2) and rosiglitazone rapidly induce the transcription of suppressor of cytokine signaling (SOCS) 1 and 3, which in turn inhibit JAK activity in activated glial cells. In addition, Src homology 2 domain-containing protein phosphatase 2 (SHP2), another negative regulator of JAK activity, is also involved in their anti-inflammatory action. Our data suggest that 15d-PGJ(2) and rosiglitazone suppress the initiation of JAK-STAT inflammatory signaling independently of PPAR-gamma, thus attenuating brain inflammation.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"12584205","pmcid":null,"openalex_id":null,"authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":null,"license":"http://creativecommons.org/licenses/by/4.0/","oa_locations":[{"url":"https://api.elsevier.com/content/article/PII:S0021925819302674?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0021925819302674?httpAccept=text/plain","host_type":"publisher"},{"url":"https://syndication.highwire.org/content/doi/10.1074/jbc.M210819200","host_type":"publisher"},{"url":"http://www.jbc.org/content/278/17/14747.full.pdf","host_type":"Unpaywall"}],"fields_of_study":[],"mesh_terms":["Neuroglia","Astrocytes","Animals","Rats","Rats, Sprague-Dawley","Inflammation","Thiazoles","Thiazolidinediones","Prostaglandin D2","Proteins","Carrier Proteins","DNA-Binding Proteins","Trans-Activators","Proto-Oncogene Proteins","Receptors, Cytoplasmic and Nuclear","Transcription Factors","Repressor Proteins","Anti-Inflammatory Agents","Signal Transduction","Protein Biosynthesis","Gene Expression Regulation","Phosphorylation","STAT1 Transcription Factor","STAT3 Transcription Factor","Suppressor of Cytokine Signaling Proteins","Protein-Tyrosine Kinases","Janus Kinase 2","Janus Kinase 1","Suppressor of Cytokine Signaling 1 Protein","Suppressor of Cytokine Signaling 3 Protein","Rosiglitazone"],"keywords":[],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-11T21:20:53.198458Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}