{"doi":"10.1074/jbc.m209649200","title":"Scavenger Receptors Class A-I/II and CD36 Are the Principal Receptors Responsible for the Uptake of Modified Low Density Lipoprotein Leading to Lipid Loading in Macrophages","abstract":null,"journal":"Journal of Biological Chemistry","year":2002,"id":630127,"datarank":1.040159581489284,"base_score":6.934397209928558,"endowment":6.934397209928558,"self_citation_contribution":1.040159581489284,"citation_network_contribution":0.0,"self_endowment_contribution":1.040159581489284,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1026,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":646710,"name":"Maria Febbraio","orcid":"0000-0001-7142-8440","position":1,"is_corresponding":false},{"id":278591,"name":"Eugene A. Podrez","orcid":"0000-0002-9550-6965","position":2,"is_corresponding":false},{"id":236657,"name":"Kathryn J. Moore","orcid":"0000-0003-2505-2547","position":3,"is_corresponding":false},{"id":1632290,"name":"Lorna Andersson","orcid":null,"position":4,"is_corresponding":false},{"id":1632291,"name":"Stephanie Koehn","orcid":null,"position":5,"is_corresponding":false},{"id":1632292,"name":"Jeongmi S. Rhee","orcid":null,"position":6,"is_corresponding":false},{"id":1632293,"name":"Roy Silverstein","orcid":null,"position":7,"is_corresponding":false},{"id":1631432,"name":"Henry F. Hoff","orcid":null,"position":8,"is_corresponding":false},{"id":644626,"name":"Mason W. Freeman","orcid":"0000-0002-5254-9244","position":9,"is_corresponding":false},{"id":1596436,"name":"Vidya V. Kunjathoor","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Scavenger Receptors Class A-I/II and CD36 Are the Principal Receptors Responsible for the Uptake of Modified Low Density Lipoprotein Leading to Lipid Loading in Macrophages","abstract":"Modification of low density lipoprotein (LDL) can result in the avid uptake of these lipoproteins via a family of macrophage transmembrane proteins referred to as scavenger receptors (SRs). The genetic inactivation of either of two SR family members, SR-A or CD36, has been shown previously to reduce oxidized LDL uptake in vitro and atherosclerotic lesions in mice. Several other SRs are reported to bind modified LDL, but their contribution to macrophage lipid accumulation is uncertain. We generated mice lacking both SR-A and CD36 to determine their combined impact on macrophage lipid uptake and to assess the contribution of other SRs to this process. We show that SR-A and CD36 account for 75-90% of degradation of LDL modified by acetylation or oxidation. Cholesteryl ester derived from modified lipoproteins fails to accumulate in macrophages taken from the double null mice, as assessed by histochemistry and gas chromatography-mass spectrometry. These results demonstrate that SR-A and CD36 are responsible for the preponderance of modified LDL uptake in macrophages and that other scavenger receptors do not compensate for their absence.","is_dataset_classified":null,"base_score":6.934397209928558,"endowment":6.934397209928558,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"12376530","pmcid":null,"openalex_id":"https://openalex.org/W1975905715","authors":[],"funders":[{"funder_name":"NHLBI NIH HHS","grant_id":"HL 66678","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"F32 HL 10366","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"HL 45098","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"HL 53315","title":null}],"total_grants":4,"fwci":20.3355,"citation_percentile":0.99636482,"influential_citations":0,"citation_trend":[{"year":2012,"count":49},{"year":2013,"count":59},{"year":2014,"count":44},{"year":2015,"count":43},{"year":2016,"count":52},{"year":2017,"count":53},{"year":2018,"count":57},{"year":2019,"count":42},{"year":2020,"count":49},{"year":2021,"count":50},{"year":2022,"count":58},{"year":2023,"count":52},{"year":2024,"count":43},{"year":2025,"count":38},{"year":2026,"count":21}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"http://www.jbc.org/article/S0021925819329837/pdf","host_type":"journal"},{"url":"http://www.jbc.org/article/S0021925819329837/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0021925819329837?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0021925819329837?httpAccept=text/plain","host_type":"publisher"},{"url":"https://syndication.highwire.org/content/doi/10.1074/jbc.M209649200","host_type":"publisher"},{"url":"https://doi.org/10.1074/jbc.m209649200","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/12376530","host_type":"repository"}],"fields_of_study":["Cholesterol and Lipid Metabolism","Cancer, Lipids, and Metabolism","Peroxisome Proliferator-Activated Receptors"],"mesh_terms":["Animals","Cholesterol","Copper","Enzyme-Linked Immunosorbent Assay","Flow Cytometry","Foam Cells","Genotype","Lipoproteins, LDL","Macrophages","Gas Chromatography-Mass Spectrometry","Membrane Proteins","Mice, Inbred C57BL","Mice, Transgenic","Oxygen","Protein Binding","Receptors, Immunologic","Time Factors","Cytokines","Receptors, Lipoprotein","CD36 Antigens","Lipid Metabolism","Receptors, Scavenger","Scavenger Receptors, Class A","Scavenger Receptors, Class B","Mice"],"keywords":["Scavenger receptor","CD36","Receptor","Chemistry","Lipoprotein","Macrophage","Low-density lipoprotein","Biochemistry","Foam cell","LDL receptor","In vitro","Cholesterol"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T20:33:09.697406Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}