{"doi":"10.1074/jbc.m205503200","title":"Cyclin F Is Degraded during G2-M by Mechanisms Fundamentally Different from Other Cyclins","abstract":null,"journal":"Journal of Biological Chemistry","year":2002,"id":591104,"datarank":2.9693095594227463,"base_score":4.406719247264253,"endowment":4.406719247264253,"self_citation_contribution":0.6610078870896381,"citation_network_contribution":2.3083016723331085,"self_endowment_contribution":0.6610078870896381,"citer_contribution":2.3083016723331085,"corpus_percentile":null,"corpus_rank":null,"citation_count":81,"citer_count":62,"citers_with_citation_signal":52,"citers_with_endowment":52,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1512332,"name":"Wai Yi Siu","orcid":null,"position":1,"is_corresponding":false},{"id":1512333,"name":"Cain H. Yam","orcid":null,"position":2,"is_corresponding":false},{"id":1512334,"name":"Anita Lau","orcid":null,"position":3,"is_corresponding":false},{"id":1512335,"name":"Randy Y.C. Poon","orcid":null,"position":4,"is_corresponding":false},{"id":1224131,"name":"Tsz Kan Fung","orcid":"0000-0001-5285-6239","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Cyclin F Is Degraded during G2-M by Mechanisms Fundamentally Different from Other Cyclins","abstract":"Cyclin F, a cyclin that can form SCF complexes and bind to cyclin B, oscillates in the cell cycle with a pattern similar to cyclin A and cyclin B. Ectopic expression of cyclin F arrests the cell cycle in G(2)/M. How the level of cyclin F is regulated during the cell cycle is completely obscure. Here we show that, similar to cyclin A, cyclin F is degraded when the spindle assembly checkpoint is activated and accumulates when the DNA damage checkpoint is activated. Cyclin F is a very unstable protein throughout much of the cell cycle. Unlike other cyclins, degradation of cyclin F is independent of ubiquitination and proteasome-mediated pathways. Interestingly, proteolysis of cyclin F is likely to involve metalloproteases. Rapid destruction of cyclin F does not require the N-terminal F-box motif but requires the COOH-terminal PEST sequences. The PEST region alone is sufficient to interfere with the degradation of cyclin F and confer instability when fused to cyclin A. These data show that although cyclin F is degraded at similar time as the mitotic cyclins, the underlying mechanisms are entirely distinct.","is_dataset_classified":null,"base_score":4.406719247264253,"endowment":4.406719247264253,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"12122006","pmcid":null,"openalex_id":"https://openalex.org/W2089201777","authors":[],"funders":[],"total_grants":0,"fwci":1.8961,"citation_percentile":0.8535745,"influential_citations":0,"citation_trend":[{"year":2012,"count":8},{"year":2013,"count":6},{"year":2014,"count":6},{"year":2015,"count":3},{"year":2016,"count":3},{"year":2017,"count":4},{"year":2018,"count":3},{"year":2019,"count":3},{"year":2020,"count":3},{"year":2021,"count":3},{"year":2022,"count":2},{"year":2023,"count":2},{"year":2024,"count":1},{"year":2025,"count":2}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1074/jbc.m205503200","host_type":"journal"},{"url":"https://doi.org/10.1074/jbc.m205503200","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0021925818367437?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0021925818367437?httpAccept=text/plain","host_type":"publisher"},{"url":"https://syndication.highwire.org/content/doi/10.1074/jbc.M205503200","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/12122006","host_type":"repository"},{"url":"https://authors.library.caltech.edu/3379/","host_type":"repository"},{"url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.541.8948","host_type":""},{"url":"https://kclpure.kcl.ac.uk/portal/en/publications/19ed14f3-a0e5-45de-9f30-ab2322a48bf5","host_type":"repository"},{"url":"http://repository.hkust.edu.hk/ir/Record/1783.1-46336","host_type":"repository"},{"url":"http://www.scopus.com/record/display.url?eid=2-s2.0-0037144583&origin=inward","host_type":"repository"}],"fields_of_study":["Cancer-related Molecular Pathways","Ubiquitin and proteasome pathways","Microtubule and mitosis dynamics","Cell Line","Cyclins","DNA Damage","G2 Phase","Humans","Hydrolysis","Mitosis","Recombinant Proteins","S Phase"],"mesh_terms":["Cell Line","DNA Damage","Humans","Hydrolysis","Mitosis","Recombinant Proteins","G2 Phase","S Phase","Cyclins"],"keywords":["Cyclin A2","Cyclin B","Cyclin A","Cyclin D","Cyclin E","Cyclin","Cyclin-dependent kinase complex","Cell biology","Cyclin B1","Cell cycle","Biology","Cyclin D1","Biochemistry","Cyclin-dependent kinase 1","Cell"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-25T14:21:36.814381Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}