{"doi":"10.1074/jbc.m110.108290","title":"Thioredoxin-interacting Protein (Txnip) Gene Expression","abstract":null,"journal":"Journal of Biological Chemistry","year":2010,"id":611926,"datarank":0.6496100010429497,"base_score":4.330733340286331,"endowment":4.330733340286331,"self_citation_contribution":0.6496100010429497,"citation_network_contribution":0.0,"self_endowment_contribution":0.6496100010429497,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":75,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":8,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1575272,"name":"Tin Fan Chai","orcid":null,"position":1,"is_corresponding":false},{"id":1575274,"name":"Hongpeng He","orcid":null,"position":2,"is_corresponding":false},{"id":530067,"name":"Thilo Hagen","orcid":"0000-0001-7834-0601","position":3,"is_corresponding":false},{"id":1402056,"name":"Yan Luo","orcid":"0000-0001-9282-3212","position":4,"is_corresponding":false},{"id":1575271,"name":"Fa-Xing Yu","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Thioredoxin-interacting Protein (Txnip) Gene Expression","abstract":"Thioredoxin-interacting protein (Txnip) has important functions in regulating cellular metabolism including glucose utilization; the expression of the Txnip gene is sensitive to the availability of glucose and other fuels. Here, we show that Txnip expression is down-regulated at the transcriptional level by diverse inhibitors of mitochondrial oxidative phosphorylation (OXPHOS). The effect of these OXPHOS inhibitors is mediated by earlier identified carbohydrate-response elements (ChoREs) on the Txnip promoter and the ChoRE-associated transcription factors Max-like protein X (MLX) and MondoA (or carbohydrate-response element-binding protein (ChREBP)) involved in glucose-induced Txnip expression, suggesting that inhibited oxidative phosphorylation compromises glucose-induced effects on Txnip expression. We also show that the OXPHOS inhibitors repress the Txnip transcription most likely by inducing the glycolytic rate, and increased glycolytic flux decreases the levels of glycolytic intermediates important for the function of MLX and MondoA (or ChREBP). Our findings suggest that the Txnip expression is tightly correlated with glycolytic flux, which is regulated by oxidative phosphorylation status. The identified link between the Txnip expression and glycolytic activity implies a mechanism by which the cellular glucose uptake/homeostasis is regulated in response to various metabolic cues, oxidative phosphorylation status, and other physiological signals, and this may facilitate our efforts toward understanding metabolism in normal or cancer 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biology and oxidative stress","ATP Synthase and ATPases Research","Cancer, Hypoxia, and Metabolism","Biology","Medicine","Chemistry","Basic Helix-Loop-Helix Leucine Zipper Transcription Factors","Blotting, Western","Carrier Proteins","Cell Line","Chromatin Immunoprecipitation","Gene Expression","Glycolysis","HeLa Cells","Humans","Mitochondria","Oxidative Phosphorylation","RNA Interference","Reverse Transcriptase Polymerase Chain Reaction","Signal Transduction"],"mesh_terms":["Carrier Proteins","Cell Line","Glycolysis","HeLa Cells","Humans","Mitochondria","Oxidative Phosphorylation","Blotting, Western","Signal Transduction","Gene Expression","Reverse Transcriptase Polymerase Chain Reaction","RNA Interference","Chromatin Immunoprecipitation","Basic Helix-Loop-Helix Leucine Zipper Transcription Factors","Hela Cells"],"keywords":["TXNIP","Thioredoxin-Interacting Protein","Carbohydrate-responsive element-binding protein","Oxidative phosphorylation","Glycolysis","Phosphorylation","Thioredoxin","Transcription factor","Biology","Cell biology","Biochemistry","Carbohydrate metabolism","Gene expression","Chemistry","Metabolism","Oxidative stress","Gene"],"sdg_mappings":[],"linked_datasets":[{"doi":"10.6084/m9.figshare.13633196.v1","title":"Additional file 1 of Pharmacological activation of pyruvate kinase M2 reprograms glycolysis leading to TXNIP depletion and AMPK activation in breast cancer cells","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.13633196","title":"Additional file 1 of Pharmacological activation of pyruvate kinase M2 reprograms glycolysis leading to TXNIP depletion and AMPK activation in breast cancer cells","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.13633199.v1","title":"Additional file 2 of Pharmacological activation of pyruvate kinase M2 reprograms glycolysis leading to TXNIP depletion and AMPK activation in breast cancer 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