{"doi":"10.1074/jbc.273.5.2954","title":"Galectin-4 and Galectin-6 Are Two Closely Related Lectins Expressed in Mouse Gastrointestinal Tract","abstract":null,"journal":"Journal of Biological Chemistry","year":1998,"id":611776,"datarank":0.6892679775201885,"base_score":4.59511985013459,"endowment":4.59511985013459,"self_citation_contribution":0.6892679775201885,"citation_network_contribution":0.0,"self_endowment_contribution":0.6892679775201885,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":98,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1252587,"name":"Céline Colnot","orcid":"0000-0001-8423-8718","position":1,"is_corresponding":false},{"id":1529798,"name":"Françoise Poirier","orcid":null,"position":2,"is_corresponding":false},{"id":1574762,"name":"Kathryn J. Nani","orcid":null,"position":3,"is_corresponding":false},{"id":189321,"name":"Samuel H. Barondes","orcid":null,"position":4,"is_corresponding":false},{"id":670398,"name":"Hakon Leffler","orcid":"0000-0003-4482-8945","position":5,"is_corresponding":false},{"id":1574761,"name":"Michael A. Gitt","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Galectin-4 and Galectin-6 Are Two Closely Related Lectins Expressed in Mouse Gastrointestinal Tract","abstract":"Galectins are a family of carbohydrate-binding proteins that share a conserved sequence and affinity for beta-galactosides. Some, such as galectin-1, are isolated as dimers and have a single carbohydrate recognition domain (CRD) in each monomer, whereas others, such as galectin-4, are isolated as monomers and have two CRDs in a single polypeptide chain. In the course of studying mouse colon mRNA for galectin-4, we detected a related mRNA that encodes a new galectin that also has two CRDs in a single peptide chain. The new galectin, galectin-6, lacks a 24-amino acid stretch in the link region between the two CRDs that is present in galectin-4. Otherwise, these two galectins have 83% amino acid identity. Expression of both galectin-4 and galectin-6 is confined to the epithelial cells of the embryonic and adult gastrointestinal tract. Galectin-4 is expressed at about equal levels in colon and small intestine but much less in stomach, whereas galectin-6 is expressed at about equal levels throughout the gastrointestinal tract.","is_dataset_classified":null,"base_score":4.59511985013459,"endowment":4.59511985013459,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"9446608","pmcid":null,"openalex_id":"https://openalex.org/W2131493236","authors":[],"funders":[{"funder_name":"NHLBI NIH HHS","grant_id":"HL38627","title":null}],"total_grants":1,"fwci":2.0778,"citation_percentile":0.87890255,"influential_citations":0,"citation_trend":[{"year":2012,"count":4},{"year":2013,"count":2},{"year":2014,"count":2},{"year":2015,"count":6},{"year":2016,"count":4},{"year":2017,"count":2},{"year":2018,"count":2},{"year":2020,"count":2},{"year":2021,"count":4},{"year":2023,"count":2},{"year":2026,"count":1}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1074/jbc.273.5.2954","host_type":"journal"},{"url":"https://doi.org/10.1074/jbc.273.5.2954","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0021925818949823?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0021925818949823?httpAccept=text/plain","host_type":"publisher"},{"url":"https://syndication.highwire.org/content/doi/10.1074/jbc.273.5.2954","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/9446608","host_type":"repository"}],"fields_of_study":["Galectins and Cancer Biology"],"mesh_terms":["Animals","Base Sequence","Colon","Digestive System","Female","Gastric Mucosa","Hemagglutinins","Intestine, Small","Molecular Sequence Data","Pregnancy","RNA, Messenger","Blotting, Northern","Sequence Alignment","In Situ Hybridization","Lectins","Galectins","Galectin 4","Mice"],"keywords":["Galectin","Galectin-3","Gastrointestinal tract","Biology","Lectin","Peptide","Messenger RNA","Amino acid","Peptide sequence","Molecular biology","Biochemistry","Gene","Immunology"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-01T22:29:28.367706Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}