{"doi":"10.1074/jbc.271.31.18329","title":"Tetrodotoxin Reverses Brevetoxin Allosteric Inhibition of Scorpion α-Toxin Binding on Rat Brain Sodium Channels","abstract":null,"journal":"Journal of Biological Chemistry","year":1996,"id":633049,"datarank":0.44166584687496613,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"self_citation_contribution":0.44166584687496613,"citation_network_contribution":0.0,"self_endowment_contribution":0.44166584687496613,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1641148,"name":"Fran¸ois Sampieri","orcid":null,"position":1,"is_corresponding":false},{"id":1641151,"name":"Hervé Rochat","orcid":null,"position":2,"is_corresponding":false},{"id":657466,"name":"Dalia Gordon","orcid":"0000-0003-0929-6138","position":3,"is_corresponding":false},{"id":844305,"name":"Sandrine Cestèle","orcid":"0000-0002-5982-1562","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Tetrodotoxin Reverses Brevetoxin Allosteric Inhibition of Scorpion α-Toxin Binding on Rat Brain Sodium Channels","abstract":"Voltage-sensitive sodium channels are responsible for the initiation of action potentials in many excitable cells. Several neurotoxins bind to distinct receptor sites on sodium channels and reveal strong allosteric interactions among them. Scorpion alpha toxins, which inhibit sodium channel inactivation by binding to receptor site 3, have been very important tools to study sodium channel structure and function. Recently, we have shown that brevetoxin induce a strong negative allosteric modulation on scorpion alpha-toxin binding on rat brain sodium channels, in contrast to previously published studies. In this report we have examined the reasons for this discrepancy and found new, unexpected allosteric interactions between the tetrodotoxin and brevetoxin receptor sites, using scorpion alpha-toxin as sensitive probe for subtle conformational changes on sodium channels. Tetrodotoxin reverses the negative modulation induced by brevetoxin on scorpion alpha-toxin binding, revealing new dynamic interactions in sodium channel structure.","is_dataset_classified":null,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"8702472","pmcid":null,"openalex_id":"https://openalex.org/W1991087563","authors":[],"funders":[],"total_grants":0,"fwci":0.9296,"citation_percentile":0.73274558,"influential_citations":0,"citation_trend":[{"year":2015,"count":1}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"http://www.jbc.org/article/S0021925818319847/pdf","host_type":"journal"},{"url":"http://www.jbc.org/article/S0021925818319847/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0021925818319847?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S0021925818319847?httpAccept=text/plain","host_type":"publisher"},{"url":"https://syndication.highwire.org/content/doi/10.1074/jbc.271.31.18329","host_type":"publisher"},{"url":"https://doi.org/10.1074/jbc.271.31.18329","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/8702472","host_type":"repository"},{"url":"https://hal.science/hal-02353220","host_type":"repository"}],"fields_of_study":["Ion channel regulation and function","Nicotinic Acetylcholine Receptors Study","Marine Toxins and Detection Methods"],"mesh_terms":["Polyether Toxins","Allosteric Site","Animals","Brain","Drug Interactions","Marine Toxins","Neurotoxins","Scorpion Venoms","Tetrodotoxin","Sodium Channels","Molecular Structure","Rats, Wistar","Reptilian Proteins","Oxocins","Rats","In Vitro Techniques"],"keywords":["Allosteric regulation","Sodium channel","Scorpion toxin","Tetrodotoxin","Biophysics","Toxin","Scorpion Venoms","Chemistry","Neurotoxin","Sodium","Receptor","Binding site","Biochemistry","Pharmacology","Biology","Scorpion","Venom"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life below water"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T10:50:25.078247Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}