{"doi":"10.1073/pnas.98.2.591","title":"Loss of imprinting of the insulin-like growth factor II gene occurs by biallelic methylation in a core region of\n            <i>H19</i>\n            -associated CTCF-binding sites in colorectal cancer","abstract":"We hypothesize that loss of imprinting (LOI) of the insulin-like growth factor II (IGF2) gene is associated with a predisposition to sporadic colorectal cancer. We confirmed a previously known strong correlation between LOI and microsatellite instability and showed that LOI was not a consequence of microsatellite instability or mismatch repair deficiency. LOI of IGF2 correlated strongly with biallelic hypermethylation of a core of five CpG sites in the insulator region of IGF2/H19, which is a known CTCF-binding element. As this methylation-dependent LOI was present in both tumors and normal colonic mucosa, it is possible that hypermethylation creates a field defect predisposing to cancer.","journal":"Proceedings of the National Academy of Sciences","year":2000,"id":12475,"datarank":0.7574784010874307,"base_score":5.049856007249537,"endowment":5.049856007249537,"self_citation_contribution":0.7574784010874307,"citation_network_contribution":0.0,"self_endowment_contribution":0.7574784010874307,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":155,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.0422,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2000-12-19","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":82752,"name":"George Eliot Hospital NHS Trust, Nuneaton, UK","orcid":null,"position":1,"is_corresponding":false},{"id":29233,"name":"Päivi Peltomäki","orcid":null,"position":2,"is_corresponding":false},{"id":13076,"name":"Randi Istrup Pedersen","orcid":"0000-0002-7236-4001","position":3,"is_corresponding":false},{"id":11271,"name":"Karen L. Mohlke","orcid":"0000-0001-6721-153X","position":4,"is_corresponding":false},{"id":4794,"name":"Albert de la Chapelle","orcid":"0000-0001-9345-9248","position":5,"is_corresponding":false},{"id":29241,"name":"Païvi Peltomäki","orcid":"0000-0001-8819-2980","position":6,"is_corresponding":false},{"id":13140,"name":"Hidewaki Nakagawa","orcid":"0000-0003-1807-772X","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}