{"doi":"10.1073/pnas.96.19.10729","title":"A homeobox gene,\n            <i>vax2</i>\n            , controls the patterning of the eye dorsoventral axis","abstract":"<jats:p>\n            We have identified a transcription factor specifically expressed in the developing vertebrate eye. We named this gene\n            <jats:italic>vax2</jats:italic>\n            because of the high degree of sequence similarity to the recently described\n            <jats:italic>vax1</jats:italic>\n            . Both in the human and mouse genomes,\n            <jats:italic>vax2</jats:italic>\n            is localized in the vicinity of the\n            <jats:italic>emx1</jats:italic>\n            gene. This mapping assignment, together with the previously reported colocalization of\n            <jats:italic>Vax1</jats:italic>\n            and\n            <jats:italic>Emx2</jats:italic>\n            in mouse, indicates that the\n            <jats:italic>vax</jats:italic>\n            and the\n            <jats:italic>emx</jats:italic>\n            genes may be organized in clusters.\n            <jats:italic>vax2</jats:italic>\n            has a remarkable expression domain confined to the ventral portion of the prospective neural retina in mouse, human, and\n            <jats:italic>Xenopus</jats:italic>\n            . The overexpression of either the frog\n            <jats:italic>Xvax2</jats:italic>\n            or the human\n            <jats:italic>VAX2</jats:italic>\n            in\n            <jats:italic>Xenopus</jats:italic>\n            embryos leads to an aberrant eye phenotype and, in particular, determines a ventralizing effect on the developing eye. The expression domain of the transcription factor\n            <jats:italic>Xpax2</jats:italic>\n            , normally confined to the ventral developing retina, extends to the dorsal region of the retina after overexpression of\n            <jats:italic>vax2</jats:italic>\n            . On the other hand, the expression of\n            <jats:italic>Xvent2</jats:italic>\n            , a molecular marker of the dorsal retina, is strongly reduced. Furthermore,\n            <jats:italic>vax2</jats:italic>\n            overexpression induces a striking expansion of the optic stalk, a structure deriving from the ventralmost region of the eye vesicle. Altogether, these data indicate that\n            <jats:italic>vax2</jats:italic>\n            plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle.\n          </jats:p>","journal":"Proceedings of the National Academy of Sciences","year":1999,"id":24760,"datarank":6.619704657380346,"base_score":5.0238805208462765,"endowment":5.0238805208462765,"self_citation_contribution":0.7535820781269416,"citation_network_contribution":5.866122579253405,"self_endowment_contribution":0.7535820781269416,"citer_contribution":5.866122579253405,"corpus_percentile":null,"corpus_rank":null,"citation_count":151,"citer_count":141,"citers_with_citation_signal":132,"citers_with_endowment":132,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":147602,"name":"Giuseppe Lupo","orcid":null,"position":1,"is_corresponding":false},{"id":147603,"name":"Alessandro Bulfone","orcid":null,"position":2,"is_corresponding":false},{"id":147604,"name":"Massimiliano Andreazzoli","orcid":null,"position":3,"is_corresponding":false},{"id":147605,"name":"Margherita Mariani","orcid":null,"position":4,"is_corresponding":false},{"id":147606,"name":"Francoise Fougerousse","orcid":null,"position":5,"is_corresponding":false},{"id":147607,"name":"Gian Giacomo Consalez","orcid":null,"position":6,"is_corresponding":false},{"id":147608,"name":"Giuseppe Borsani","orcid":null,"position":7,"is_corresponding":false},{"id":147609,"name":"Jacques S. Beckmann","orcid":null,"position":8,"is_corresponding":false},{"id":147610,"name":"Giuseppina Barsacchi","orcid":null,"position":9,"is_corresponding":false},{"id":121646,"name":"Andrea Ballabio","orcid":null,"position":10,"is_corresponding":false},{"id":56958,"name":"Sandro Banfi","orcid":"0000-0002-6541-8833","position":11,"is_corresponding":false},{"id":147601,"name":"Anna Maria Barbieri","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":5.0238805208462765,"endowment":5.0238805208462765,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"10485894","pmcid":"PMC17951","openalex_id":"https://openalex.org/W2098429986","authors":[],"funders":[{"funder_name":"Telethon","grant_id":"TGM06S01","title":null},{"funder_name":"Telethon","grant_id":"TGM97000","title":null}],"total_grants":2,"fwci":3.3051,"citation_percentile":0.92696784,"influential_citations":9,"citation_trend":[{"year":2012,"count":6},{"year":2013,"count":5},{"year":2014,"count":6},{"year":2015,"count":6},{"year":2016,"count":2},{"year":2017,"count":4},{"year":2018,"count":5},{"year":2019,"count":2},{"year":2020,"count":5},{"year":2021,"count":3},{"year":2022,"count":4},{"year":2023,"count":6},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"green","license":null,"oa_locations":[{"url":"http://www.pnas.org/content/96/19/10729","host_type":"repository"},{"url":"https://europepmc.org/articles/pmc17951?pdf=render","host_type":"GREEN"},{"url":"http://www.pnas.org/content/96/19/10729","host_type":"repository"},{"url":"https://pnas.org/doi/pdf/10.1073/pnas.96.19.10729","host_type":"publisher"},{"url":"http://hdl.handle.net/11573/950947","host_type":"repository"},{"url":"https://doi.org/10.1073/pnas.96.19.10729","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/10485894","host_type":"repository"},{"url":"https://iris.unil.ch/handle/iris/67231","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/17951","host_type":"repository"},{"url":"https://serval.unil.ch/notice/serval:BIB_4340739D9C56","host_type":"repository"}],"fields_of_study":["Developmental Biology and Gene Regulation","Retinal Development and Disorders","Cell Adhesion Molecules Research","Biology","Medicine","Amino Acid Sequence","Animals","Body Patterning","DNA, Complementary","Eye","Gene Expression Regulation, Developmental","Genetic Linkage","Homeodomain Proteins","Humans","In Situ Hybridization","Larva","Mice","Molecular Sequence Data","Phenotype","Physical Chromosome Mapping","Retina","Sequence Homology, Amino Acid","Time Factors","Tissue Distribution","Xenopus","Xenopus Proteins"],"mesh_terms":["Amino Acid Sequence","Animals","Eye","Humans","Larva","Genetic Linkage","Molecular Sequence Data","Phenotype","Retina","Time Factors","Tissue Distribution","Xenopus","Sequence Homology, Amino Acid","In Situ Hybridization","DNA, Complementary","Homeodomain Proteins","Gene Expression Regulation, Developmental","Body Patterning","Physical Chromosome Mapping","Xenopus Proteins","Mice"],"keywords":["Xenopus","Biology","Optic vesicle","Homeobox","Eye development","Retina","Colocalization","Eye Proteins","Transcription factor","Cell biology","Neural plate","Slit","PAX6","Optic cup (embryology)","Netrin","Gene","Genetics","Axon guidance","Neuroscience","Axon"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"gen"},{"name":"uniprot"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-07T23:10:50.713913Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}