{"doi":"10.1073/pnas.95.18.10866","title":"A viral gene that activates lytic cycle expression of Kaposi’s sarcoma-associated herpesvirus","abstract":"<jats:p>Herpesviruses exist in two states, latency and a lytic productive cycle. Here we identify an immediate-early gene encoded by Kaposi’s sarcoma-associated herpesvirus (KSHV)/human herpesvirus eight (HHV8) that activates lytic cycle gene expression from the latent viral genome. The gene is a homologue of Rta, a transcriptional activator encoded by Epstein–Barr virus (EBV). KSHV/Rta activated KSHV early lytic genes, including virus-encoded interleukin 6 and polyadenylated nuclear RNA, and a late gene, small viral capsid antigen. In cells dually infected with Epstein–Barr virus and KSHV, each Rta activated only autologous lytic cycle genes. Expression of viral cytokines under control of the KSHV/Rta gene is likely to contribute to the pathogenesis of KSHV-associated diseases.</jats:p>","journal":"Proceedings of the National Academy of Sciences","year":1998,"id":35199,"datarank":13.649352116652691,"base_score":6.403574197934815,"endowment":6.403574197934815,"self_citation_contribution":0.9605361296902224,"citation_network_contribution":12.688815986962469,"self_endowment_contribution":0.9605361296902224,"citer_contribution":12.688815986962469,"corpus_percentile":null,"corpus_rank":null,"citation_count":603,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":55.0,"fair_percentile":76.1664988251091,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":180788,"name":"Su-Fang 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cancers and disorders","Cytomegalovirus and herpesvirus research","Parvovirus B19 Infection Studies","Biology","Medicine","Amino Acid Sequence","Base Sequence","Cloning, Molecular","DNA Primers","DNA, Complementary","Gene Expression Regulation, Neoplastic","Genes, Viral","Herpesvirus 4, Human","Herpesvirus 8, Human","Humans","Molecular Sequence Data","Sarcoma, Kaposi","Sequence Homology, Amino Acid","Transcription, Genetic","Tumor Cells, Cultured","Virus Activation"],"mesh_terms":["Amino Acid Sequence","Base Sequence","Cloning, Molecular","Herpesvirus 4, Human","Genes, Viral","Humans","Molecular Sequence Data","Sarcoma, Kaposi","Transcription, Genetic","Tumor Cells, Cultured","Virus Activation","Gene Expression Regulation, Neoplastic","Sequence Homology, Amino Acid","DNA Primers","DNA, Complementary","Herpesvirus 8, Human"],"keywords":["Lytic cycle","Kaposi's sarcoma-associated herpesvirus","Biology","Virology","Gene","Virus latency","Gammaherpesvirinae","Virus","Herpesviridae","Gene 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