{"doi":"10.1073/pnas.94.26.14400","title":"Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex","abstract":"<jats:p>\n            Nuclear hormone receptors are potent repressors of transcription in the unliganded state. We describe here the cloning of a nuclear receptor corepressor that we call SUN-CoR (Small Unique Nuclear receptor CoRepressor), which shows no homology to previously described nuclear hormone receptor corepressors, N-CoR, or SMRT. SUN-CoR is a highly basic, 16-kDa nuclear protein that is expressed at high levels in adult tissues and is induced during adipocyte and myogenic differentiation. SUN-CoR potentiates transcriptional repression by thyroid hormone receptor and RevErb\n            <jats:italic>in vivo</jats:italic>\n            , represses transcription when fused to a heterologous DNA binding domain, and interacts with RevErb as well as with thyroid hormone receptor\n            <jats:italic>in vitro</jats:italic>\n            . SUN-CoR also interacts with N-CoR and SMRT\n            <jats:italic>in vitro</jats:italic>\n            and with endogenous N-CoR in cells. We conclude that SUN-CoR is a corepressor and may function as an additional component of the complex involved in transcriptional repression by unliganded and orphan nuclear hormone receptors.\n          </jats:p>","journal":"Proceedings of the National Academy of Sciences","year":1997,"id":24779,"datarank":5.79137502173681,"base_score":4.919980925828125,"endowment":4.919980925828125,"self_citation_contribution":0.7379971388742189,"citation_network_contribution":5.053377882862591,"self_endowment_contribution":0.7379971388742189,"citer_contribution":5.053377882862591,"corpus_percentile":null,"corpus_rank":null,"citation_count":136,"citer_count":123,"citers_with_citation_signal":107,"citers_with_endowment":107,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":147684,"name":"Jessica Dawson","orcid":null,"position":1,"is_corresponding":false},{"id":73069,"name":"Robert M. Lavinsky","orcid":null,"position":2,"is_corresponding":false},{"id":20022,"name":"Christopher K. Glass","orcid":"0000-0003-4344-3592","position":3,"is_corresponding":false},{"id":73079,"name":"Michael G. Rosenfeld","orcid":"0000-0002-1572-156X","position":4,"is_corresponding":false},{"id":39746,"name":"Mitchell A. Lazar","orcid":"0000-0001-8653-1280","position":5,"is_corresponding":false},{"id":147429,"name":"Iris Zamir","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":4.919980925828125,"endowment":4.919980925828125,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"9405624","pmcid":"PMC24996","openalex_id":"https://openalex.org/W2056806913","authors":[],"funders":[{"funder_name":"NIDDK NIH HHS","grant_id":"DK45586","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK045586","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"T32 GM007170","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"5P32GM07170","title":null}],"total_grants":4,"fwci":7.8392,"citation_percentile":0.97774719,"influential_citations":3,"citation_trend":[{"year":2012,"count":6},{"year":2013,"count":2},{"year":2014,"count":2},{"year":2015,"count":2},{"year":2016,"count":1},{"year":2017,"count":2},{"year":2018,"count":1},{"year":2019,"count":2},{"year":2022,"count":2},{"year":2024,"count":1}],"oa_status":"green","license":null,"oa_locations":[{"url":"https://europepmc.org/articles/pmc24996?pdf=render","host_type":"GREEN"},{"url":"https://pnas.org/doi/pdf/10.1073/pnas.94.26.14400","host_type":"publisher"},{"url":"https://doi.org/10.1073/pnas.94.26.14400","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/9405624","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/24996","host_type":"repository"}],"fields_of_study":["Estrogen and related hormone effects","Adipose Tissue and Metabolism","Retinoids in leukemia and cellular processes","Biology","Medicine","Amino Acid Sequence","Animals","Base Sequence","Cloning, Molecular","Mice","Molecular Sequence Data","Nuclear Proteins","Organ Specificity","Receptors, Cell Surface","Receptors, Cytoplasmic and Nuclear","Sequence Analysis","Signal Transduction"],"mesh_terms":["Amino Acid Sequence","Animals","Base Sequence","Cloning, Molecular","Molecular Sequence Data","Nuclear Proteins","Organ Specificity","Receptors, Cell Surface","Signal Transduction","Sequence Analysis","Receptors, Cytoplasmic and Nuclear","Mice"],"keywords":["Corepressor","Thyroid hormone receptor","Nuclear receptor","Nuclear receptor co-repressor 1","Thyroid hormone receptor beta","Thyroid hormone receptor alpha","Small heterodimer partner","Psychological repression","Repressor","Biology","Hormone receptor","Nuclear receptor coactivator 1","Cell biology","Transcription factor","Molecular biology","Receptor","Genetics","Gene expression","Gene"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"gen"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-07T23:13:21.826580Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}