{"doi":"10.1073/pnas.94.22.11980","title":"Xenopus Zic\n 3, a primary regulator both in neural and neural crest development","abstract":"\n Xenopus Zic3\n is a\n Xenopus\n homologue of mouse\n Zic\n and\n Drosophila\n pair-rule gene,\n odd-paired\n . We show here that\n Zic3\n has significant roles both in neural and neural crest development in\n Xenopus\n embryo. Expression of\n Zic3\n is first detected in prospective neural plate region at gastrulation. Onset of the expression was earlier than most proneural genes and followed\n chordin\n expression. The expression was induced by blockade of BMP4 signal. Overexpression of\n Zic3\n resulted in hyperplastic neural and neural crest derived tissue. In animal cap explant, the overexpression of\n Zic3\n induced expression of all the proneural genes and neural crest marker genes. These findings suggest that\n Zic3\n can determine the ectodermal cell fate and promote the earliest step of neural and neural crest development.\n ","journal":"Proceedings of the National Academy of Sciences","year":1997,"id":622094,"datarank":0.8251887315817092,"base_score":5.501258210544727,"endowment":5.501258210544727,"self_citation_contribution":0.8251887315817092,"citation_network_contribution":0.0,"self_endowment_contribution":0.8251887315817092,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":244,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":119488,"name":"Takeharu Nagai","orcid":"0000-0003-2650-9895","position":1,"is_corresponding":false},{"id":1282588,"name":"Jun Aruga","orcid":"0000-0001-7936-1375","position":2,"is_corresponding":false},{"id":134493,"name":"Katsuhiko Mikoshiba","orcid":null,"position":3,"is_corresponding":false},{"id":1606717,"name":"Katsunori Nakata","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Xenopus Zic\n 3, a primary regulator both in neural and neural crest development","abstract":"\n Xenopus Zic3\n is a\n Xenopus\n homologue of mouse\n Zic\n and\n Drosophila\n pair-rule gene,\n odd-paired\n . We show here that\n Zic3\n has significant roles both in neural and neural crest development in\n Xenopus\n embryo. Expression of\n Zic3\n is first detected in prospective neural plate region at gastrulation. Onset of the expression was earlier than most proneural genes and followed\n chordin\n expression. The expression was induced by blockade of BMP4 signal. Overexpression of\n Zic3\n resulted in hyperplastic neural and neural crest derived tissue. In animal cap explant, the overexpression of\n Zic3\n induced expression of all the proneural genes and neural crest marker genes. These findings suggest that\n Zic3\n can determine the ectodermal cell fate and promote the earliest step of neural and neural crest development.\n ","is_dataset_classified":null,"base_score":5.501258210544727,"endowment":5.501258210544727,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"9342348","pmcid":"PMC23676","openalex_id":"https://openalex.org/W2084617272","authors":[],"funders":[],"total_grants":0,"fwci":4.9642,"citation_percentile":0.96239873,"influential_citations":0,"citation_trend":[{"year":2012,"count":14},{"year":2013,"count":7},{"year":2014,"count":4},{"year":2015,"count":4},{"year":2016,"count":1},{"year":2017,"count":2},{"year":2018,"count":8},{"year":2019,"count":4},{"year":2020,"count":4},{"year":2021,"count":2},{"year":2022,"count":4},{"year":2023,"count":2},{"year":2024,"count":6},{"year":2025,"count":1},{"year":2026,"count":2}],"oa_status":"green","license":null,"oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/23676","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/23676","host_type":"repository"},{"url":"https://pnas.org/doi/pdf/10.1073/pnas.94.22.11980","host_type":"publisher"},{"url":"https://doi.org/10.1073/pnas.94.22.11980","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/9342348","host_type":"repository"}],"fields_of_study":["Developmental Biology and Gene Regulation","Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities"],"mesh_terms":["Animals","Antigens, Differentiation","Cloning, Molecular","Ectoderm","Embryonic Induction","Gastrula","Molecular Sequence Data","Nervous System","Neural Crest","Recombinant Proteins","Transcription Factors","Xenopus","Signal Transduction","Polymerase Chain Reaction","In Situ Hybridization","Homeodomain Proteins","Gene Expression Regulation, Developmental","Bone Morphogenetic Proteins","Xenopus Proteins","Bone Morphogenetic Protein 4"],"keywords":["Neural crest","Xenopus","Neural plate","Biology","Gastrulation","Neural development","Neural fold","Cranial neural crest","Cell biology","Regulator","Embryo","Gene","Neural cell","Genetics","Embryogenesis","Cell"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"gen"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T18:11:54.991468Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}