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The predominant variant in sporadic AD was A beta-(1-40), whereas the principal A beta variant in nondemented elderly controls was A beta-(1-42). The ratio A beta-(1-40)/A beta-(1-42) differed by 10-fold between brains from nondemented controls and those with sporadic AD.</jats:p>","journal":"Proceedings of the National Academy of Sciences","year":1994,"id":596748,"datarank":0.9241810982542616,"base_score":6.161207321695077,"endowment":6.161207321695077,"self_citation_contribution":0.9241810982542616,"citation_network_contribution":0.0,"self_endowment_contribution":0.9241810982542616,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":473,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1528456,"name":"A Schierhorn","orcid":null,"position":1,"is_corresponding":false},{"id":1528457,"name":"U Hellman","orcid":null,"position":2,"is_corresponding":false},{"id":1528458,"name":"L Lannfelt","orcid":null,"position":3,"is_corresponding":false},{"id":1528459,"name":"A D Roses","orcid":null,"position":4,"is_corresponding":false},{"id":1528460,"name":"L O Tjernberg","orcid":null,"position":5,"is_corresponding":false},{"id":1528461,"name":"J Silberring","orcid":null,"position":6,"is_corresponding":false},{"id":1528462,"name":"S E Gandy","orcid":null,"position":7,"is_corresponding":false},{"id":1528463,"name":"B Winblad","orcid":null,"position":8,"is_corresponding":false},{"id":1528465,"name":"P Greengard","orcid":null,"position":9,"is_corresponding":false},{"id":1528455,"name":"J Näslund","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging.","abstract":"<jats:p>The Alzheimer A beta amyloid peptide (A beta) is the principal proteinaceous component of amyloid associated with Alzheimer disease (AD). We have determined the relative abundance of A beta structural variants present in amyloid from brains of 10 individuals with sporadic AD, 2 individuals with familial AD carrying specific mutations in the Alzheimer amyloid precursor protein gene, and 5 nondemented elderly controls. A procedure of isolation based on the extreme insolubility of A beta amyloid was used. The purified, nondigested A beta was analyzed by N-terminal sequencing and electrospray-ionization mass spectrometry. Three principal A beta variants were detected--A beta-(1-40), A beta-(1-42), and A beta-(11-42)--in all brains analyzed. The predominant variant in sporadic AD was A beta-(1-40), whereas the principal A beta variant in nondemented elderly controls was A beta-(1-42). The ratio A beta-(1-40)/A beta-(1-42) differed by 10-fold between brains from nondemented controls and those with sporadic AD.</jats:p>","is_dataset_classified":null,"base_score":6.161207321695077,"endowment":6.161207321695077,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"8078890","pmcid":"PMC44609","openalex_id":"https://openalex.org/W1989972829","authors":[],"funders":[{"funder_name":"NIA NIH HHS","grant_id":"AG-09464","title":null},{"funder_name":"NIA NIH HHS","grant_id":"AG-10491","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"HL 49571-02","title":null}],"total_grants":3,"fwci":5.483,"citation_percentile":0.96466239,"influential_citations":0,"citation_trend":[{"year":2012,"count":20},{"year":2013,"count":10},{"year":2014,"count":9},{"year":2015,"count":18},{"year":2016,"count":11},{"year":2017,"count":25},{"year":2018,"count":15},{"year":2019,"count":20},{"year":2020,"count":14},{"year":2021,"count":17},{"year":2022,"count":21},{"year":2023,"count":33},{"year":2024,"count":13},{"year":2025,"count":13},{"year":2026,"count":4}],"oa_status":"green","license":null,"oa_locations":[{"url":"https://pnas.org/doi/pdf/10.1073/pnas.91.18.8378","host_type":"publisher"},{"url":"https://doi.org/10.1073/pnas.91.18.8378","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/8078890","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/44609","host_type":"repository"}],"fields_of_study":["Alzheimer's disease research and treatments","Bioinformatics and Genomic Networks","Computational Drug Discovery Methods","Aged","Aging","Alzheimer Disease","Amino Acid Sequence","Amyloid beta-Peptides","Amyloid beta-Protein Precursor","Cerebral Cortex","Female","Humans","Male","Mass Spectrometry","Molecular Sequence Data","Mutation"],"mesh_terms":["Aged","Aging","Alzheimer Disease","Amino Acid Sequence","Cerebral Cortex","Female","Humans","Male","Molecular Sequence Data","Mutation","Mass Spectrometry","Amyloid beta-Peptides","Amyloid beta-Protein Precursor"],"keywords":["Alzheimer's disease","BETA (programming language)","Amyloid beta","Amyloid (mycology)","Senile plaques","Degenerative disease","Peptide","Amyloid precursor protein","Biochemistry of Alzheimer's disease","Biology","Chemistry","Molecular biology","Pathology","Biochemistry","Medicine","Central nervous system disease","Disease","Neuroscience"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T11:08:50.071191Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}