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Deletional analyses localized the transcriptional repressor activity of CREB-2 to a 102-amino acid COOH-terminal region (amino acids 249-351) that contains the leucine-zipper and basic domains of the molecule. These results demonstrate that CRE-dependent transcription can be both positively and negatively regulated by structurally related members of the ATF/CREB family.</jats:p>","journal":"Proceedings of the National Academy of Sciences","year":1992,"id":676246,"datarank":14.842421471611296,"base_score":5.579729825986222,"endowment":5.579729825986222,"self_citation_contribution":0.8369594738979335,"citation_network_contribution":14.005461997713363,"self_endowment_contribution":0.8369594738979335,"citer_contribution":14.005461997713363,"corpus_percentile":null,"corpus_rank":null,"citation_count":264,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1766982,"name":"G D Morle","orcid":null,"position":1,"is_corresponding":false},{"id":1766983,"name":"J Huggenvik","orcid":null,"position":2,"is_corresponding":false},{"id":1766985,"name":"M D Uhler","orcid":null,"position":3,"is_corresponding":false},{"id":1766986,"name":"J M Leiden","orcid":null,"position":4,"is_corresponding":false},{"id":1766979,"name":"B A Karpinski","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element.","abstract":"<jats:p>The cAMP response element (CRE) is an octanucleotide motif (TGACGTCA) that mediates diverse transcriptional regulatory effects. 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