{"doi":"10.1073/pnas.85.9.3066","title":"Identification of a GTP-binding protein alpha subunit that lacks an apparent ADP-ribosylation site for pertussis toxin.","abstract":"<jats:p>Recent molecular cloning of cDNA for the alpha subunit of bovine transducin (a guanine nucleotide-binding regulatory protein, or G protein) has revealed the presence of two retinal-specific transducins, called Tr and Tc, which are expressed in rod or cone photoreceptor cells. In a further study of G-protein diversity and signal transduction in the retina, we have identified a G-protein alpha subunit, which we refer to as Gz alpha, by isolating a human retinal cDNA clone that cross-hybridizes at reduced stringency with bovine Tr alpha-subunit cDNA. The deduced amino acid sequence of Gz alpha is 41-67% identical with those of other known G-protein alpha subunits. However, the 355-residue Gz alpha lacks a consensus site for ADP-ribosylation by pertussis toxin, and its amino acid sequence varies within a number of regions that are strongly conserved among all of the other G-protein alpha subunits. We suggest that Gz alpha, which appears to be highly expressed in neural tissues, represents a member of a subfamily of G proteins that mediate signal transduction in pertussis toxin-insensitive systems.</jats:p>","journal":"Proceedings of the National Academy of Sciences","year":1988,"id":25754,"datarank":14.712147846557322,"base_score":5.53338948872752,"endowment":5.53338948872752,"self_citation_contribution":0.8300084233091282,"citation_network_contribution":13.882139423248194,"self_endowment_contribution":0.8300084233091282,"citer_contribution":13.882139423248194,"corpus_percentile":null,"corpus_rank":null,"citation_count":252,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":150708,"name":"K K Yoshimoto","orcid":null,"position":1,"is_corresponding":false},{"id":150709,"name":"P Eversole-Cire","orcid":null,"position":2,"is_corresponding":false},{"id":150710,"name":"M I Simon","orcid":null,"position":3,"is_corresponding":false},{"id":150707,"name":"H K Fong","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":5.53338948872752,"endowment":5.53338948872752,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"3129724","pmcid":"PMC280144","openalex_id":"https://openalex.org/W2070111612","authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"GM34236","title":null}],"total_grants":1,"fwci":18.4735,"citation_percentile":0.99546485,"influential_citations":6,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":2},{"year":2015,"count":2},{"year":2016,"count":2},{"year":2017,"count":2},{"year":2019,"count":2},{"year":2020,"count":3},{"year":2021,"count":3},{"year":2022,"count":2},{"year":2023,"count":4},{"year":2024,"count":3},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"green","license":null,"oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/280144","host_type":"repository"},{"url":"https://europepmc.org/articles/pmc280144?pdf=render","host_type":"GREEN"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/280144","host_type":"repository"},{"url":"https://pnas.org/doi/pdf/10.1073/pnas.85.9.3066","host_type":"publisher"},{"url":"https://doi.org/10.1073/pnas.85.9.3066","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/3129724","host_type":"repository"},{"url":"https://authors.library.caltech.edu/7708/","host_type":"repository"}],"fields_of_study":["Cellular transport and secretion","Protein Kinase Regulation and GTPase Signaling","Hereditary Neurological Disorders","Biology","Medicine","Adenosine Diphosphate Ribose","Amino Acid Sequence","Base Sequence","Cloning, Molecular","DNA","GTP-Binding Proteins","Humans","Molecular Sequence Data","Nucleic Acid Hybridization","Pertussis Toxin","RNA, Messenger","Virulence Factors, Bordetella"],"mesh_terms":["Adenosine Diphosphate Ribose","Amino Acid Sequence","Base Sequence","Cloning, Molecular","DNA","Humans","Molecular Sequence Data","Nucleic Acid Hybridization","Virulence Factors, Bordetella","RNA, Messenger","GTP-Binding Proteins","Pertussis Toxin"],"keywords":["Transducin","G alpha subunit","Pertussis toxin","Biology","G protein","Gi alpha subunit","Interleukin 10 receptor, alpha subunit","Protein subunit","Peptide sequence","Interleukin 5 receptor alpha subunit","Molecular biology","GTP-binding protein regulators","Complementary DNA","ADP-ribosylation","SCN3A","Gs alpha subunit","Binding protein","Gamma-aminobutyric acid receptor subunit alpha-1","Gamma subunit","Biochemistry","Signal transduction","Gene","Enzyme"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-08T07:41:58.662665Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}