{"doi":"10.1073/pnas.84.23.8355","title":"A cellular protein, activating transcription factor, activates transcription of multiple E1A-inducible adenovirus early promoters.","abstract":"<jats:p>We have examined the relationship between sequence-specific DNA-binding proteins that activate transcription of E1A-inducible adenovirus early promoters. Factors previously referred to as E4F1 and E2A-EF bind to the E4 and E2A promoters, respectively. We demonstrate here that E4F1 and E2A-EF have identical DNA-binding specificity. Moreover, E4F1 and E2A-EF both activate transcription of the E4 and E2A promoters in vitro. These findings demonstrate that E4F1 and E2A-EF are the same factor, which we have designated activating transcription factor, or ATF. In addition to the E4 and E2A promoters, ATF binds to an important functional element of the E1A-inducible E3 promoter. Interaction of a common activator protein, ATF, with multiple E1A-inducible early viral promoters, suggests a significant role for ATF in E1A-mediated transcriptional activation.</jats:p>","journal":"Proceedings of the National Academy of Sciences","year":1987,"id":20862,"datarank":15.326488394107852,"base_score":5.598421958998375,"endowment":5.598421958998375,"self_citation_contribution":0.8397632938497563,"citation_network_contribution":14.486725100258095,"self_endowment_contribution":0.8397632938497563,"citer_contribution":14.486725100258095,"corpus_percentile":null,"corpus_rank":null,"citation_count":269,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":136464,"name":"T Y Hai","orcid":null,"position":1,"is_corresponding":false},{"id":136465,"name":"L SivaRaman","orcid":null,"position":2,"is_corresponding":false},{"id":136466,"name":"B Thimmappaya","orcid":null,"position":3,"is_corresponding":false},{"id":136467,"name":"H C Hurst","orcid":null,"position":4,"is_corresponding":false},{"id":136468,"name":"N C Jones","orcid":null,"position":5,"is_corresponding":false},{"id":136469,"name":"M R Green","orcid":null,"position":6,"is_corresponding":false},{"id":136463,"name":"K A Lee","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":5.598421958998375,"endowment":5.598421958998375,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"2960975","pmcid":"PMC299541","openalex_id":"https://openalex.org/W2059358614","authors":[],"funders":[],"total_grants":0,"fwci":30.0055,"citation_percentile":0.99790743,"influential_citations":9,"citation_trend":[{"year":2012,"count":4},{"year":2013,"count":3},{"year":2014,"count":1},{"year":2015,"count":1},{"year":2017,"count":2},{"year":2018,"count":2},{"year":2019,"count":1},{"year":2020,"count":1},{"year":2021,"count":6},{"year":2023,"count":2},{"year":2024,"count":1}],"oa_status":"green","license":null,"oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/299541","host_type":"repository"},{"url":"https://europepmc.org/articles/pmc299541?pdf=render","host_type":"GREEN"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/299541","host_type":"repository"},{"url":"https://pnas.org/doi/pdf/10.1073/pnas.84.23.8355","host_type":"publisher"},{"url":"https://doi.org/10.1073/pnas.84.23.8355","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/2960975","host_type":"repository"},{"url":"http://europepmc.org/pmc/articles/PMC299541","host_type":"repository"}],"fields_of_study":["Virus-based gene therapy research","Animal Genetics and Reproduction","Viral Infectious Diseases and Gene Expression in Insects","Biology","Medicine","Adenovirus Early Proteins","Adenoviruses, Human","Base Sequence","Binding Sites","DNA-Binding Proteins","Gene Expression Regulation","Oncogene Proteins, Viral","Promoter Regions, Genetic","Transcription Factors","Transcription, Genetic"],"mesh_terms":["Adenoviruses, Human","Base Sequence","Binding Sites","DNA-Binding Proteins","Gene Expression Regulation","Oncogene Proteins, Viral","Promoter Regions, Genetic","Transcription Factors","Transcription, Genetic","Adenovirus Early Proteins"],"keywords":["Promoter","Response element","Transcription factor","Molecular biology","Biology","DNA-binding protein","Activator (genetics)","General transcription factor","Sp1 transcription factor","Transcription (linguistics)","Activating transcription factor 2","Cell biology","Genetics","Gene","Gene expression"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-06T12:41:11.738529Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}