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The pattern of sequence homology supports the hypothesis that the carboxyl-terminal two-thirds of the molecules constitute the enzymatic activity cores, and the amino-terminal thirds of the molecules constitute domains for substrate specificity.</jats:p>","journal":"Proceedings of the National Academy of Sciences","year":1987,"id":32764,"datarank":11.477768041129881,"base_score":5.204006687076795,"endowment":5.204006687076795,"self_citation_contribution":0.7806010030615194,"citation_network_contribution":10.697167038068361,"self_endowment_contribution":0.7806010030615194,"citer_contribution":10.697167038068361,"corpus_percentile":null,"corpus_rank":null,"citation_count":181,"citer_count":179,"citers_with_citation_signal":167,"citers_with_endowment":167,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":172810,"name":"F D Ledley","orcid":null,"position":1,"is_corresponding":false},{"id":172811,"name":"L L Reed","orcid":null,"position":2,"is_corresponding":false},{"id":172812,"name":"S L Woo","orcid":null,"position":3,"is_corresponding":false},{"id":172809,"name":"H E Grenett","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":5.204006687076795,"endowment":5.204006687076795,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"3475690","pmcid":"PMC298896","openalex_id":"https://openalex.org/W2067043949","authors":[],"funders":[{"funder_name":"NICHD NIH HHS","grant_id":"HD17711","title":null}],"total_grants":1,"fwci":8.3826,"citation_percentile":0.98547311,"influential_citations":4,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":2},{"year":2014,"count":4},{"year":2016,"count":2},{"year":2018,"count":3},{"year":2019,"count":2},{"year":2020,"count":3},{"year":2021,"count":4},{"year":2022,"count":1},{"year":2023,"count":1},{"year":2024,"count":2},{"year":2025,"count":1}],"oa_status":"green","license":null,"oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/298896","host_type":"repository"},{"url":"https://europepmc.org/articles/pmc298896?pdf=render","host_type":"GREEN"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/298896","host_type":"repository"},{"url":"https://pnas.org/doi/pdf/10.1073/pnas.84.16.5530","host_type":"publisher"},{"url":"https://doi.org/10.1073/pnas.84.16.5530","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/3475690","host_type":"repository"}],"fields_of_study":["Metabolism and Genetic Disorders","Microbial Metabolic Engineering and Bioproduction","Amino Acid Enzymes and Metabolism","Biology","Medicine","Chemistry","Amino Acid Sequence","Animals","Antibodies","Base Sequence","Brain Stem","Cloning, Molecular","Cross Reactions","DNA","Nucleic Acid Hybridization","Phenylalanine Hydroxylase","Pineal Gland","RNA, Messenger","Rabbits","Rats","Tryptophan Hydroxylase"],"mesh_terms":["Amino Acid Sequence","Animals","Antibodies","Base Sequence","Brain Stem","Cloning, Molecular","Cross Reactions","DNA","Nucleic Acid Hybridization","Phenylalanine Hydroxylase","Pineal Gland","Rabbits","RNA, Messenger","Tryptophan Hydroxylase","Rats"],"keywords":["Phenylalanine hydroxylase","Tryptophan hydroxylase","Tyrosine hydroxylase","Complementary DNA","Biology","Biochemistry","Amino acid","Phenylalanine","Tyrosine 3-Monooxygenase","Molecular biology","Tryptophan","Tyrosine","Peptide sequence","Aromatic amino acids","Enzyme","Gene","Serotonin"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-09T14:29:18.354282Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}