{"doi":"10.1073/pnas.72.4.1523","title":"Two classes of translational control RNA: their role in the regulation of  protein synthesis.","abstract":"<jats:p>Two classes of translation control RNA (tcRNA) have been isolated from embryonic chick muscle. One of these classes, the tcRNA isolated from messenger ribonucleoprotein particles (mRNP-tcRNA), is effective in inhibiting the translation of mRNP-mRNA while having little if any effect on polysomal mRNA. The other class, polysome-tcRNA, has no effect on mRNP-mRNA while it stimulates the translation of polysomal mRNA. The mRNP tcRNA contains approximately 50 percent uridylate residues and forms small but stable hybrids with poly (A), while polysome-tcRNA contains fewer uridylate residues and is much less effective in forming a hybrid with poly (A). A proposed model concerning the role of these two classes of tcRNA in the regulation of protein synthesis is presented.</jats:p>","journal":"Proceedings of the National Academy of Sciences","year":1975,"id":675500,"datarank":6.261968558412649,"base_score":4.709530201312334,"endowment":4.709530201312334,"self_citation_contribution":0.7064295301968502,"citation_network_contribution":5.555539028215799,"self_endowment_contribution":0.7064295301968502,"citer_contribution":5.555539028215799,"corpus_percentile":null,"corpus_rank":null,"citation_count":110,"citer_count":97,"citers_with_citation_signal":88,"citers_with_endowment":88,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1764965,"name":"D S Kennedy","orcid":null,"position":1,"is_corresponding":false},{"id":1764966,"name":"S M Heywood","orcid":null,"position":2,"is_corresponding":false},{"id":1764964,"name":"A J Bester","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Two classes of translational control RNA: their role in the regulation of  protein synthesis.","abstract":"<jats:p>Two classes of translation control RNA (tcRNA) have been isolated from embryonic chick muscle. One of these classes, the tcRNA isolated from messenger ribonucleoprotein particles (mRNP-tcRNA), is effective in inhibiting the translation of mRNP-mRNA while having little if any effect on polysomal mRNA. The other class, polysome-tcRNA, has no effect on mRNP-mRNA while it stimulates the translation of polysomal mRNA. The mRNP tcRNA contains approximately 50 percent uridylate residues and forms small but stable hybrids with poly (A), while polysome-tcRNA contains fewer uridylate residues and is much less effective in forming a hybrid with poly (A). 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