{"doi":"10.1073/pnas.71.8.3134","title":"Interaction of the Operator of the Tryptophan Operon with Repressor","abstract":"<jats:p>\n                    Transcription studies\n                    <jats:italic>in vitro</jats:italic>\n                    on repression of the tryptophan operon of\n                    <jats:italic>Escherichia coli</jats:italic>\n                    show that partially purified\n                    <jats:italic>trp</jats:italic>\n                    repressor binds specifically to DNA containing the\n                    <jats:italic>trp</jats:italic>\n                    operator with a repressor-operator dissociation constant of about 0.2 nM in 0.12 M salt at 37°, a value consistent with the extent of\n                    <jats:italic>trp</jats:italic>\n                    operon regulation\n                    <jats:italic>in vivo</jats:italic>\n                    . The half-life of the\n                    <jats:italic>trp</jats:italic>\n                    repressor-\n                    <jats:italic>trp</jats:italic>\n                    operator complex is less than 2 min\n                    <jats:italic>in vitro</jats:italic>\n                    in 0.12 M salt.\n                  </jats:p>","journal":"Proceedings of the National Academy of Sciences","year":1974,"id":658665,"datarank":0.6238324625039509,"base_score":4.1588830833596715,"endowment":4.1588830833596715,"self_citation_contribution":0.6238324625039509,"citation_network_contribution":0.0,"self_endowment_contribution":0.6238324625039509,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":63,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":117284,"name":"Charles Yanofsky","orcid":null,"position":1,"is_corresponding":false},{"id":122093,"name":"John K. Rose","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Interaction of the Operator of the Tryptophan Operon with Repressor","abstract":"<jats:p>\n                    Transcription studies\n                    <jats:italic>in vitro</jats:italic>\n                    on repression of the tryptophan operon of\n                    <jats:italic>Escherichia coli</jats:italic>\n                    show that partially purified\n                    <jats:italic>trp</jats:italic>\n                    repressor binds specifically to DNA containing the\n                    <jats:italic>trp</jats:italic>\n                    operator with a repressor-operator dissociation constant of about 0.2 nM in 0.12 M salt at 37°, a value consistent with the extent of\n                    <jats:italic>trp</jats:italic>\n                    operon regulation\n                    <jats:italic>in vivo</jats:italic>\n                    . The half-life of the\n                    <jats:italic>trp</jats:italic>\n                    repressor-\n                    <jats:italic>trp</jats:italic>\n                    operator complex is less than 2 min\n                    <jats:italic>in vitro</jats:italic>\n                    in 0.12 M salt.\n                  </jats:p>","is_dataset_classified":null,"base_score":4.1588830833596715,"endowment":4.1588830833596715,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"4528605","pmcid":"PMC388636","openalex_id":"https://openalex.org/W2048769188","authors":[],"funders":[],"total_grants":0,"fwci":0.6587,"citation_percentile":0.65653389,"influential_citations":0,"citation_trend":[{"year":2014,"count":1},{"year":2015,"count":1},{"year":2016,"count":2},{"year":2026,"count":1}],"oa_status":"green","license":null,"oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/388636","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/388636","host_type":"repository"},{"url":"https://pnas.org/doi/pdf/10.1073/pnas.71.8.3134","host_type":"publisher"},{"url":"https://doi.org/10.1073/pnas.71.8.3134","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/4528605","host_type":"repository"}],"fields_of_study":["Diffusion and Search Dynamics","DNA and Nucleic Acid Chemistry","Bacterial Genetics and Biotechnology"],"mesh_terms":["Coliphages","DNA Viruses","Enzyme Repression","Genes, Regulator","Half-Life","Nucleic Acid Hybridization","Operon","DNA-Directed RNA Polymerases","Templates, Genetic","Transcription, Genetic","Tritium","Tryptophan"],"keywords":["trp operon","Operon","Repressor","Tryptophan","Operator (biology)","gal operon","Transcription (linguistics)","L-arabinose operon","lac operon","Lac repressor","Biochemistry","Psychological repression","Chemistry","Dissociation constant","Escherichia coli","Biology","Transcription factor","Gene","Amino acid","Gene expression"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T04:58:01.730788Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}