{"doi":"10.1073/pnas.70.10.2832","title":"Strychnine Binding Associated with Glycine Receptors of the Central Nervous System","abstract":"<jats:p>\n                    [\n                    <jats:sup>3</jats:sup>\n                    H]Strychnine binds to synaptic-membrane fractions of the spinal cord in a selective fashion, indicating an interaction with postsynaptic glycine receptors. Displacement of strychnine by glycine and other amino acids parallels their glycine-like neurophysiologic activity. The regional localization of strychnine binding in the central nervous system correlates closely with endogenous glycine concentrations. In subcellular fractionation experiments, strychnine binding is most enhanced in synaptic-membrane fractions. Strychnine binding is saturable, with affinity constants for glycine and strychnine of 10 and 0.03 μM, respectively.\n                  </jats:p>","journal":"Proceedings of the National Academy of Sciences","year":1973,"id":657884,"datarank":20.28426690052889,"base_score":5.966146739123692,"endowment":5.966146739123692,"self_citation_contribution":0.8949220108685539,"citation_network_contribution":19.389344889660336,"self_endowment_contribution":0.8949220108685539,"citer_contribution":19.389344889660336,"corpus_percentile":null,"corpus_rank":null,"citation_count":389,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":79953,"name":"Solomon H. Snyder","orcid":"0000-0002-6818-7022","position":1,"is_corresponding":false},{"id":1717385,"name":"Anne B. Young","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Strychnine Binding Associated with Glycine Receptors of the Central Nervous System","abstract":"<jats:p>\n                    [\n                    <jats:sup>3</jats:sup>\n                    H]Strychnine binds to synaptic-membrane fractions of the spinal cord in a selective fashion, indicating an interaction with postsynaptic glycine receptors. Displacement of strychnine by glycine and other amino acids parallels their glycine-like neurophysiologic activity. The regional localization of strychnine binding in the central nervous system correlates closely with endogenous glycine concentrations. In subcellular fractionation experiments, strychnine binding is most enhanced in synaptic-membrane fractions. Strychnine binding is saturable, with affinity constants for glycine and strychnine of 10 and 0.03 μM, respectively.\n                  </jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"4200724","pmcid":"PMC427119","openalex_id":null,"authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":null,"license":null,"oa_locations":[{"url":"https://pnas.org/doi/pdf/10.1073/pnas.70.10.2832","host_type":"publisher"}],"fields_of_study":[],"mesh_terms":["Brain","Brain Stem","Spinal Cord","Synaptic Membranes","Cell Nucleus","Mitochondria","Microsomes","Animals","Haplorhini","Macaca","Rats","Tritium","Strychnine","Amino Acids","Glycine","Receptors, Drug","Cell Fractionation","Binding, Competitive","Kinetics","Male","In Vitro Techniques"],"keywords":[],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T02:37:53.855184Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}