{"doi":"10.1073/pnas.2433987100","title":"Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1","abstract":"<jats:p>The use of histone deacetylase (HDAC) inhibitors has revealed an essential role for deacetylation in transcription of IFN-responsive genes. The HDAC1 protein associates with both signal transducer and activator of transcription (STAT) 1 and STAT2, and IFN-α stimulation induces deacetylation of histone H4. Inhibition of HDAC1 by small interfering RNA (siRNA) decreases IFN-α responsiveness whereas expression of HDAC1 augments the IFN-α response, demonstrating that HDAC1 modulates IFN-α-induced transcription. Importantly, the innate antiviral response is inhibited in the absence of deacetylase activity. The requirement for deacetylase is shared by IFN-γ transcription response and may represent a general requirement for STAT-dependent gene expression.</jats:p>","journal":"Proceedings of the National Academy of Sciences","year":2003,"id":14940,"datarank":11.510594530202914,"base_score":5.641907070938114,"endowment":5.641907070938114,"self_citation_contribution":0.8462860606407172,"citation_network_contribution":10.664308469562197,"self_endowment_contribution":0.8462860606407172,"citer_contribution":10.664308469562197,"corpus_percentile":null,"corpus_rank":null,"citation_count":281,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":115879,"name":"Curt M. 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