{"doi":"10.1073/pnas.2310174120","title":"Neutral lysophosphatidylcholine mediates α-synuclein-induced synaptic vesicle clustering","abstract":"α-synuclein (α-Syn) is a presynaptic protein that is involved in Parkinson’s and other neurodegenerative diseases and binds to negatively charged phospholipids. Previously, we reported that α-Syn clusters synthetic proteoliposomes that mimic synaptic vesicles. This vesicle-clustering activity depends on a specific interaction of α-Syn with anionic phospholipids. Here, we report that α-Syn surprisingly also interacts with the neutral phospholipid lysophosphatidylcholine (lysoPC). Even in the absence of anionic lipids, lysoPC facilitates α-Syn-induced vesicle clustering but has no effect on Ca 2+ -triggered fusion in a single vesicle–vesicle fusion assay. The A30P mutant of α-Syn that causes familial Parkinson disease has a reduced affinity to lysoPC and does not induce vesicle clustering. Taken together, the α-Syn–lysoPC interaction may play a role in α-Syn function.","journal":"Proceedings of the National Academy of Sciences","year":2023,"id":326322,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":29,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9547,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":759836,"name":"Chunyu Zhao","orcid":"0000-0003-0168-2130","position":1,"is_corresponding":false},{"id":1045261,"name":"Zhiqi Tian","orcid":"0000-0001-7027-9527","position":2,"is_corresponding":false},{"id":482959,"name":"Chuchu Wang","orcid":"0000-0003-2015-7331","position":3,"is_corresponding":false},{"id":1045262,"name":"Jiaqi Fan","orcid":"0009-0002-3541-7984","position":4,"is_corresponding":false},{"id":1045263,"name":"Xiao Hu","orcid":"0000-0001-9133-3705","position":5,"is_corresponding":false},{"id":1045264,"name":"Jia Tu","orcid":"0000-0003-0548-7770","position":6,"is_corresponding":false},{"id":1045877,"name":"Tihui Li","orcid":null,"position":7,"is_corresponding":false},{"id":749935,"name":"Jeremy Leitz","orcid":"0009-0009-9976-2497","position":8,"is_corresponding":false},{"id":51694,"name":"Richard A. Pfuetzner","orcid":"0000-0002-1741-2330","position":9,"is_corresponding":false},{"id":1045265,"name":"Zhengtao Liu","orcid":"0000-0001-5404-9422","position":10,"is_corresponding":false},{"id":482964,"name":"Shengnan Zhang","orcid":"0000-0003-1051-7196","position":11,"is_corresponding":false},{"id":228229,"name":"Zhaoming Su","orcid":"0000-0002-9279-1721","position":12,"is_corresponding":false},{"id":814165,"name":"Jacqueline Burré","orcid":"0000-0001-8968-248X","position":13,"is_corresponding":false},{"id":236990,"name":"Dan Li","orcid":"0000-0002-1609-1539","position":14,"is_corresponding":false},{"id":21542,"name":"Thomas C. Südhof","orcid":"0000-0003-3361-9275","position":15,"is_corresponding":false},{"id":211991,"name":"Zheng-Jiang Zhu","orcid":"0000-0002-3272-3567","position":16,"is_corresponding":false},{"id":236995,"name":"Cong Liu","orcid":"0000-0003-3425-6672","position":17,"is_corresponding":false},{"id":57565,"name":"Axel T. Brünger","orcid":"0000-0001-5121-2036","position":18,"is_corresponding":false},{"id":281294,"name":"Jiajie Diao","orcid":"0000-0003-4288-3203","position":19,"is_corresponding":false},{"id":854416,"name":"Ying Lai","orcid":"0000-0001-5347-5155","position":0,"is_corresponding":true}],"reference_count":36,"raw_metadata":null,"created_at":"2026-07-19T01:08:33.106703Z","pmid":"37883437","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}