{"doi":"10.1073/pnas.2308292120","title":"RNA-binding motif protein 10 inactivates c-Myc by partnering with ribosomal proteins uL18 and uL5","abstract":"RNA-binding motif protein 10 (RBM10) is a frequently mutated tumor suppressor in lung adenocarcinoma (LUAD). Yet, it remains unknown whether cancer-derived mutant RBM10 compromises its tumor suppression function and, if so, the molecular insight of the underlying mechanisms. Here, we show that wild-type RBM10 suppresses lung cancer cell growth and proliferation by inactivating c-Myc that is essential for cancer cell survival. RBM10 directly binds to c-Myc and promotes c-Myc's ubiquitin-dependent degradation, while RBM10 knockdown leads to the induction of c-Myc level and activity. This negative action on c-Myc is further boosted by ribosomal proteins (RPs) uL18 (RPL5) and uL5 (RPL11) via their direct binding to RBM10. Cancer-derived mutant RBM10-I316F fails to bind to uL18 and uL5 and to inactivate c-Myc, thus incapable of suppressing tumorigenesis. Our findings uncover RBM10 as a pivotal c-Myc repressor by cooperating with uL18 and uL5 in lung cancer cells, as its failure to do so upon mutation favors tumorigenesis.","journal":"Proceedings of the National Academy of Sciences","year":2023,"id":341934,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.96,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":336456,"name":"Ji Hoon Jung","orcid":"0000-0002-5644-5960","position":1,"is_corresponding":false},{"id":1078449,"name":"Hyun Min Ko","orcid":null,"position":2,"is_corresponding":false},{"id":970145,"name":"Hee‐Won Park","orcid":"0000-0002-7434-6675","position":3,"is_corresponding":false},{"id":1077976,"name":"Allyson M. Segall","orcid":"0000-0002-2590-5901","position":4,"is_corresponding":false},{"id":1078450,"name":"Roger L. Sheffmaker","orcid":null,"position":5,"is_corresponding":false},{"id":304511,"name":"Jieqiong Wang","orcid":"0000-0003-3096-0208","position":6,"is_corresponding":false},{"id":475708,"name":"Wesley D. Frey","orcid":"0000-0003-0392-5714","position":7,"is_corresponding":false},{"id":1078451,"name":"N.-A. Pham","orcid":null,"position":8,"is_corresponding":false},{"id":634295,"name":"Yongbo Wang","orcid":"0000-0003-4383-9423","position":9,"is_corresponding":false},{"id":406606,"name":"Yiwei Zhang","orcid":"0000-0001-9611-9337","position":10,"is_corresponding":false},{"id":393473,"name":"James G. Jackson","orcid":"0000-0002-2640-6442","position":11,"is_corresponding":false},{"id":336460,"name":"Shelya X. Zeng","orcid":"0000-0001-5195-9420","position":12,"is_corresponding":false},{"id":304513,"name":"Hua Lu","orcid":"0000-0002-9285-7209","position":13,"is_corresponding":false},{"id":945944,"name":"Hyemin Lee","orcid":"0000-0003-3910-5611","position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":null,"created_at":"2026-07-19T01:11:08.077724Z","pmid":"38032932","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}