{"doi":"10.1073/pnas.2221686120","title":"Mutant β <sub>1</sub> -adrenergic receptor improves REM sleep and ameliorates tau accumulation in a mouse model of tauopathy","abstract":"Sleep is essential for our well-being, and chronic sleep deprivation has unfavorable health consequences. We recently demonstrated that two familial natural short sleep (FNSS) mutations, DEC2-P384R and Npsr1-Y206H , are strong genetic modifiers of tauopathy in PS19 mice, a model of tauopathy. To gain more insight into how FNSS variants modify the tau phenotype, we tested the effect of another FNSS gene variant, Adrb1-A187V , by crossing mice with this mutation onto the PS19 background. We found that the Adrb1-A187V mutation helped restore rapid eye movement (REM) sleep and alleviated tau aggregation in a sleep–wake center, the locus coeruleus (LC), in PS19 mice. We found that ADRB1 + neurons in the central amygdala (CeA) sent projections to the LC, and stimulating CeA ADRB1+ neuron activity increased REM sleep. Furthermore, the mutant Adrb1 attenuated tau spreading from the CeA to the LC. Our findings suggest that the Adrb1-A187V mutation protects against tauopathy by both mitigating tau accumulation and attenuating tau spreading.","journal":"Proceedings of the National Academy of Sciences","year":2023,"id":342493,"datarank":0.5765104110164722,"base_score":2.70805020110221,"endowment":2.70805020110221,"self_citation_contribution":0.40620753016533157,"citation_network_contribution":0.17030288085114062,"self_endowment_contribution":0.40620753016533157,"citer_contribution":0.17030288085114062,"corpus_percentile":null,"corpus_rank":null,"citation_count":14,"citer_count":13,"citers_with_citation_signal":8,"citers_with_endowment":8,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9508,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":451354,"name":"Louis J. Ptáček","orcid":"0000-0001-5983-4454","position":1,"is_corresponding":false},{"id":451353,"name":"Ying‐Hui Fu","orcid":"0000-0002-6628-0266","position":2,"is_corresponding":false},{"id":394662,"name":"Qing Dong","orcid":"0000-0002-7819-2183","position":0,"is_corresponding":true}],"reference_count":55,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:11:12.506815Z","pmid":"37014857","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}