{"doi":"10.1073/pnas.2220120120","title":"Type III interferon drives thymic B cell activation and regulatory T cell generation","abstract":"The activation of thymic B cells is critical for their licensing as antigen presenting cells and resulting ability to mediate T cell central tolerance. The processes leading to licensing are still not fully understood. By comparing thymic B cells to activated Peyer’s patch B cells at steady state, we found that thymic B cell activation starts during the neonatal period and is characterized by TCR/CD40-dependent activation, followed by immunoglobulin class switch recombination (CSR) without forming germinal centers. Transcriptional analysis also demonstrated a strong interferon signature, which was not apparent in the periphery. Thymic B cell activation and CSR were primarily dependent on type III IFN signaling, and loss of type III IFN receptor in thymic B cells resulted in reduced thymocyte regulatory T cell (T reg ) development. Finally, from TCR deep sequencing, we estimate that licensed B cells induce development of a substantial fraction of the T reg cell repertoire. Together, these findings reveal the importance of steady-state type III IFN in generating licensed thymic B cells that induce T cell tolerance to activated B cells.","journal":"Proceedings of the National Academy of Sciences","year":2023,"id":321148,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":45,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9508,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":497485,"name":"Elise R. Breed","orcid":"0000-0001-6468-8463","position":1,"is_corresponding":false},{"id":1033824,"name":"Yosan Worota","orcid":null,"position":2,"is_corresponding":false},{"id":545558,"name":"K. Maude Ashby","orcid":"0000-0002-6297-5941","position":3,"is_corresponding":false},{"id":864289,"name":"Matouš Vobořil","orcid":"0000-0002-3672-7629","position":4,"is_corresponding":false},{"id":1033069,"name":"Tailor Mathes","orcid":"0000-0002-3179-1672","position":5,"is_corresponding":false},{"id":497484,"name":"Oscar Camilo Salgado","orcid":"0000-0002-9363-8649","position":6,"is_corresponding":false},{"id":616824,"name":"Christine H. O’Connor","orcid":null,"position":7,"is_corresponding":false},{"id":245459,"name":"Sergei V. Kotenko","orcid":"0000-0001-5694-878X","position":8,"is_corresponding":false},{"id":235914,"name":"Kristin A. Hogquist","orcid":"0000-0001-9963-5687","position":9,"is_corresponding":false},{"id":864290,"name":"Ryan J. Martinez","orcid":"0000-0002-2045-8794","position":0,"is_corresponding":true}],"reference_count":65,"raw_metadata":null,"created_at":"2026-07-19T01:07:32.611759Z","pmid":"36802427","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}