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We present the largest XL-MS dataset to date, describing 28,910 unique residue pairs captured across 4,084 unique human proteins and 2,110 unique protein–protein interactions. We show that models of proteins and their complexes predicted by AlphaFold2, and inspired and corroborated by the XL-MS data, offer opportunities to deeply mine the structural proteome and interactome and reveal mechanisms underlying protein structure and function.</jats:p>","journal":"Proceedings of the National Academy of Sciences","year":2023,"id":639256,"datarank":0.6663976884735476,"base_score":4.442651256490317,"endowment":4.442651256490317,"self_citation_contribution":0.6663976884735476,"citation_network_contribution":0.0,"self_endowment_contribution":0.6663976884735476,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":84,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1660745,"name":"Xabier Vázquez-Campos","orcid":"0000-0003-1134-5058","position":1,"is_corresponding":false},{"id":808341,"name":"Alexander Norman","orcid":"0000-0001-7908-0135","position":2,"is_corresponding":false},{"id":1660746,"name":"Clement Luong","orcid":"0000-0002-5479-2301","position":3,"is_corresponding":false},{"id":1150306,"name":"Marcus Johnson","orcid":"0009-0008-3137-3084","position":4,"is_corresponding":false},{"id":1081682,"name":"Richard J. 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