{"doi":"10.1073/pnas.2211047120","title":"The balance between gasdermin D and STING signaling shapes the severity of schistosome immunopathology","abstract":". Here, we uncover a unique balance in two critical innate pathways governing the severity of disease. In the low-pathology setting, parasite egg-stimulated dendritic cells (DCs) induce robust interferon (IFN)β production, which is dependent on the cyclic GMP-AMP synthase (cGAS)/stimulator of interferon genes (STING) cytosolic DNA sensing pathway and results in a Th2 response with suppression of proinflammatory cytokine production and Th17 cell activation. IFNβ induces signal transducer and activator of transcription (STAT)1, which suppresses CD209a, a C-type lectin receptor associated with severe disease. In contrast, in the high-pathology setting, enhanced DC expression of the pore-forming protein gasdermin D (Gsdmd) results in reduced expression of cGAS/STING, impaired IFNβ, and enhanced pyroptosis. Our findings demonstrate that cGAS/STING signaling represents a unique mechanism inducing protective type I IFN, which is counteracted by Gsdmd.","journal":"Proceedings of the National Academy of Sciences","year":2023,"id":357348,"datarank":0.3958585994422889,"base_score":2.639057329615259,"endowment":2.639057329615259,"self_citation_contribution":0.3958585994422889,"citation_network_contribution":0.0,"self_endowment_contribution":0.3958585994422889,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9539,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1107201,"name":"Ilana Shecter","orcid":null,"position":1,"is_corresponding":false},{"id":1107202,"name":"Jacob Hopkins","orcid":null,"position":2,"is_corresponding":false},{"id":1107203,"name":"Andrea Pilotta Gois","orcid":null,"position":3,"is_corresponding":false},{"id":958831,"name":"Yoelkys Morales","orcid":"0000-0001-7402-509X","position":4,"is_corresponding":false},{"id":1106829,"name":"Bijan F. Harandi","orcid":"0000-0002-5943-1716","position":5,"is_corresponding":false},{"id":654761,"name":"Shruti Sharma","orcid":"0000-0001-5423-1072","position":6,"is_corresponding":false},{"id":595795,"name":"Miguel J. Stadecker","orcid":"0000-0002-4170-4763","position":7,"is_corresponding":false},{"id":1106828,"name":"Parisa Kalantari","orcid":"0000-0002-0159-474X","position":0,"is_corresponding":true}],"reference_count":87,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:13:34.795336Z","pmid":"36943884","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}