{"doi":"10.1073/pnas.2205049120","title":"STING controls T cell memory fitness during infection through T cell-intrinsic and IDO-dependent mechanisms","abstract":"Stimulator of interferon genes (STING) signaling has been extensively studied in inflammatory diseases and cancer, while its role in T cell responses to infection is unclear. Using Listeria monocytogenes strains engineered to induce different levels of c-di-AMP, we found that high STING signals impaired T cell memory upon infection via increased Bim levels and apoptosis. Unexpectedly, reduction of TCR signal strength or T cell-STING expression decreased Bim expression, T cell apoptosis, and recovered T cell memory. We found that TCR signal intensity coupled STING signal strength to the unfolded protein response (UPR) and T cell survival. Under strong STING signaling, Indoleamine-pyrrole 2,3-dioxygenase (IDO) inhibition also reduced apoptosis and led to a recovery of T cell memory in STING sufficient CD8 T cells. Thus, STING signaling regulates CD8 T cell memory fitness through both cell-intrinsic and extrinsic mechanisms. These studies provide insight into how IDO and STING therapies could improve long-term T cell protective immunity.","journal":"Proceedings of the National Academy of Sciences","year":2023,"id":331852,"datarank":0.4943755299006494,"base_score":3.295836866004329,"endowment":3.295836866004329,"self_citation_contribution":0.4943755299006494,"citation_network_contribution":0.0,"self_endowment_contribution":0.4943755299006494,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":26,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9577,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":489172,"name":"Curtis J. Pritzl","orcid":"0000-0001-5238-5086","position":1,"is_corresponding":false},{"id":999996,"name":"Dezzarae Luera","orcid":"0000-0001-5353-7694","position":2,"is_corresponding":false},{"id":992216,"name":"Rebecca J. Newth","orcid":null,"position":3,"is_corresponding":false},{"id":328418,"name":"Karin M. Knudson","orcid":"0000-0003-0843-456X","position":4,"is_corresponding":false},{"id":456258,"name":"Vikas Saxena","orcid":"0000-0003-4816-4875","position":5,"is_corresponding":false},{"id":804204,"name":"Caitlyn Guldenpfennig","orcid":"0000-0002-9633-0869","position":6,"is_corresponding":false},{"id":514672,"name":"Diana Gil","orcid":"0000-0003-1744-3484","position":7,"is_corresponding":false},{"id":992218,"name":"Chris S. Rae","orcid":null,"position":8,"is_corresponding":false},{"id":991894,"name":"Peter Lauer","orcid":"0000-0001-9984-1392","position":9,"is_corresponding":false},{"id":298761,"name":"Mark A. Daniëls","orcid":"0000-0002-5175-9901","position":10,"is_corresponding":false},{"id":298763,"name":"Emma Teixeiro","orcid":"0000-0002-3596-5481","position":11,"is_corresponding":false},{"id":300252,"name":"Michael J. Quaney","orcid":null,"position":0,"is_corresponding":true}],"reference_count":65,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:09:25.015646Z","pmid":"36634134","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}