{"doi":"10.1073/pnas.2200713119","title":"Long-term experimental evolution decouples size and production costs in\n                    <i>Escherichia coli</i>","abstract":"<jats:title>Significance</jats:title>\n                  <jats:p>\n                    Populations of larger organisms should be more efficient in their resource use, but grow more slowly, than populations of smaller organisms. The relations between size, metabolism, and demography form the bedrock of metabolic theory, but most empirical tests have been correlative and indirect. Experimental lineages of\n                    <jats:italic>Escherichia coli</jats:italic>\n                    that evolved to make larger cells provide a unique opportunity to test how size, metabolism, and demography covary. Despite the larger cells having a relatively slower metabolism, they grow faster than smaller cells. They achieve this growth rate advantage by reducing the relative costs of producing their larger cells. That evolution can decouple the costs of production from size challenges a fundamental assumption about the connections between physiology and ecology.\n                  </jats:p>","journal":"Proceedings of the National Academy of Sciences","year":2022,"id":645707,"datarank":0.5641800173540344,"base_score":3.7612001156935624,"endowment":3.7612001156935624,"self_citation_contribution":0.5641800173540344,"citation_network_contribution":0.0,"self_endowment_contribution":0.5641800173540344,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":42,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1681472,"name":"Martino Malerba","orcid":"0000-0002-7480-4779","position":1,"is_corresponding":false},{"id":1681473,"name":"Thomas Lines","orcid":"0000-0002-6802-7694","position":2,"is_corresponding":false},{"id":1681474,"name":"Aysha L. 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The relations between size, metabolism, and demography form the bedrock of metabolic theory, but most empirical tests have been correlative and indirect. Experimental lineages of\n                    <jats:italic>Escherichia coli</jats:italic>\n                    that evolved to make larger cells provide a unique opportunity to test how size, metabolism, and demography covary. Despite the larger cells having a relatively slower metabolism, they grow faster than smaller cells. They achieve this growth rate advantage by reducing the relative costs of producing their larger cells. That evolution can decouple the costs of production from size challenges a fundamental assumption about the connections between physiology and ecology.\n                  </jats:p>","is_dataset_classified":null,"base_score":3.7612001156935624,"endowment":3.7612001156935624,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35594402","pmcid":"PMC9173777","openalex_id":"https://openalex.org/W4280507636","authors":[],"funders":[{"funder_name":"National Science Foundation","grant_id":"1951307","title":"LTREB Renewal: The Long-Term Evolution Experiment with Escherichia coli"},{"funder_name":"Australian Research Council (ARC)","grant_id":"FT170100441","title":"ARC Future Fellowships - Grant ID: FT170100441"}],"total_grants":2,"fwci":6.2406,"citation_percentile":0.97137213,"influential_citations":0,"citation_trend":[{"year":2022,"count":5},{"year":2023,"count":15},{"year":2024,"count":8},{"year":2025,"count":9},{"year":2026,"count":5}],"oa_status":"green","license":"cc-by-nc-nd","oa_locations":[{"url":"https://hdl.handle.net/2440/136987","host_type":"repository"},{"url":"https://hdl.handle.net/2440/136987","host_type":"repository"},{"url":"https://pnas.org/doi/pdf/10.1073/pnas.2200713119","host_type":"publisher"},{"url":"https://doi.org/10.1073/pnas.2200713119","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/35594402","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9173777","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC9173777","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC9173777?pdf=render","host_type":"Europe_PMC"},{"url":"https://doi.org/10.1101/2021.09.28.462250","host_type":""},{"url":"https://www.biorxiv.org/content/biorxiv/early/2021/09/28/2021.09.28.462250.full.pdf","host_type":""},{"url":"http://dx.doi.org/10.1073/pnas.2200713119","host_type":""},{"url":"https://dx.doi.org/10.1101/2021.09.28.462250","host_type":""},{"url":"https://doi.org/https://doi.org/10.1073/pnas.2200713119","host_type":""}],"fields_of_study":["Evolution and Genetic Dynamics","Physiological and biochemical adaptations","Evolutionary Game Theory and Cooperation","0301 basic medicine","0303 health sciences","03 medical and health sciences","Biological Evolution","Ecology","Escherichia coli"],"mesh_terms":["Ecology","Escherichia coli","Biological Evolution"],"keywords":["Population size","Biology","Scaling","Intraspecific competition","Population","Cell size","Leverage (statistics)","Experimental evolution","Population density","Coevolution","Generation time","Escherichia coli","Evolutionary biology","Ecology","Statistical physics","Genetics","Statistics","Mathematics","Physics","Demography","Cell biology","Metabolic Scaling","Metabolic Ecology","Damuth’s Law","612","Biological Sciences","Biological Evolution"],"sdg_mappings":[{"sdg_number":2,"sdg_label":"2. 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