{"doi":"10.1073/pnas.2123467119","title":"Noncanonical function of Capicua as a growth termination signal in <i>Drosophila</i> oogenesis","abstract":"Capicua (Cic) proteins are conserved HMG-box transcriptional repressors that control receptor tyrosine kinase (RTK) signaling responses and are implicated in human neurological syndromes and cancer. While Cic is known to exist as short (Cic-S) and long (Cic-L) isoforms with identical HMG-box and associated core regions but distinct N termini, most previous studies have focused on Cic-S, leaving the function of Cic-L unexplored. Here we show that Cic-L acts in two capacities during Drosophila oogenesis: 1) as a canonical sensor of RTK signaling in somatic follicle cells, and 2) as a regulator of postmitotic growth in germline nurse cells. In these latter cells, Cic-L behaves as a temporal signal that terminates endoreplicative growth before they dump their contents into the oocyte. We show that Cic-L is necessary and sufficient for nurse cell endoreplication arrest and induces both stabilization of CycE and down-regulation of Myc. Surprisingly, this function depends mainly on the Cic-L–specific N-terminal module, which is capable of acting independently of the Cic HMG-box–containing core. Mirroring these observations, basal metazoans possess truncated Cic-like proteins composed only of Cic-L N-terminal sequences, suggesting that this module plays unique, ancient roles unrelated to the canonical function of Cic.","journal":"Proceedings of the National Academy of Sciences","year":2022,"id":267185,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9541,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":927764,"name":"Clàudia Lagares","orcid":"0000-0001-7335-4430","position":1,"is_corresponding":false},{"id":927765,"name":"Sergio González‐Crespo","orcid":"0000-0002-4845-6969","position":2,"is_corresponding":false},{"id":341347,"name":"Pau Castel","orcid":"0000-0002-4972-4347","position":3,"is_corresponding":false},{"id":829500,"name":"Alexey Veraksa","orcid":"0000-0003-2920-080X","position":4,"is_corresponding":false},{"id":569729,"name":"Gerardo Jiménez","orcid":"0000-0003-2765-9289","position":5,"is_corresponding":false},{"id":927763,"name":"Laura Rodríguez-Muñoz","orcid":"0000-0002-3797-5827","position":0,"is_corresponding":true}],"reference_count":77,"raw_metadata":null,"created_at":"2026-07-19T00:27:02.050512Z","pmid":"35881788","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}