{"doi":"10.1073/pnas.2123202119","title":"p73α1, a p73 C-terminal isoform, regulates tumor suppression and the inflammatory response via Notch1","abstract":"Significance p73 is expressed as multiple C-terminal isoforms, but their expression and activity are largely unknown. Here, we identified p73α1 as a p73 C-terminal isoform that results from exon 12 ( E12 ) exclusion. We showed that E12 deficiency in mice leads to systemic inflammation but not spontaneous tumors. We also showed that Notch1 is regulated by p73α1 and plays a critical role in p73-dependent tumor suppression and systemic inflammation.","journal":"Proceedings of the National Academy of Sciences","year":2022,"id":288758,"datarank":0.3453877639491069,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.0,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9572,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":969504,"name":"Wensheng Yan","orcid":"0000-0001-6297-4589","position":1,"is_corresponding":false},{"id":713565,"name":"Xiangmudong Kong","orcid":null,"position":2,"is_corresponding":false},{"id":969505,"name":"Wenqiang Sun","orcid":"0000-0002-8589-639X","position":3,"is_corresponding":false},{"id":236560,"name":"Mingyi Chen","orcid":"0000-0001-6754-0480","position":4,"is_corresponding":false},{"id":323532,"name":"Jin Zhang","orcid":"0000-0002-6835-920X","position":5,"is_corresponding":false},{"id":341962,"name":"Xinbin Chen","orcid":"0000-0002-4582-6506","position":6,"is_corresponding":false},{"id":673231,"name":"Kyra Laubach","orcid":null,"position":0,"is_corresponding":true}],"reference_count":81,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:30:14.968626Z","pmid":"35617425","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}