{"doi":"10.1073/pnas.2121663119","title":"Natural disaster and immunological aging in a nonhuman primate","abstract":"= 108) the hurricane. Hurricane Maria was significantly associated with differential expression of 4% of immune-cell-expressed genes, and these effects were correlated with age-associated alterations in gene expression. We further found that individuals exposed to the hurricane had a gene expression profile that was, on average, 1.96 y older than individuals that were not-roughly equivalent to an increase in 7 to 8 y of a human life. Living through an intense hurricane and its aftermath was associated with expression of key immune genes, dysregulated proteostasis networks, and greater expression of inflammatory immune cell-specific marker genes. Together, our findings illuminate potential mechanisms through which the adversity unleashed by extreme weather and potentially other natural disasters might become biologically embedded, accelerate age-related molecular immune phenotypes, and ultimately contribute to earlier onset of disease and death.","journal":"Proceedings of the National Academy of Sciences","year":2022,"id":237047,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":63,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.957,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":267895,"name":"Kenneth L. Chiou","orcid":"0000-0001-7247-4107","position":1,"is_corresponding":false},{"id":267896,"name":"Michael J. Montague","orcid":"0000-0003-0253-4404","position":2,"is_corresponding":false},{"id":472006,"name":"Noah D. Simons","orcid":"0000-0002-9703-5802","position":3,"is_corresponding":false},{"id":267899,"name":"Julie E. Horvath","orcid":"0000-0002-6426-035X","position":4,"is_corresponding":false},{"id":267901,"name":"Angelina Ruíz-Lambides","orcid":"0000-0003-0733-4110","position":5,"is_corresponding":false},{"id":267902,"name":"Melween I. Martínez","orcid":"0000-0003-1030-9506","position":6,"is_corresponding":false},{"id":250515,"name":"James P. Higham","orcid":"0000-0002-1133-2030","position":7,"is_corresponding":false},{"id":267903,"name":"Lauren J. N. Brent","orcid":"0000-0002-1202-1939","position":8,"is_corresponding":false},{"id":246475,"name":"Michael L. Platt","orcid":"0000-0003-3912-8821","position":9,"is_corresponding":false},{"id":109246,"name":"Noah Snyder‐Mackler","orcid":"0000-0003-3026-6160","position":10,"is_corresponding":false},{"id":267898,"name":"Marina M. Watowich","orcid":"0000-0003-4144-4225","position":0,"is_corresponding":true}],"reference_count":94,"raw_metadata":null,"created_at":"2026-07-19T00:22:08.925400Z","pmid":"35131902","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}