{"doi":"10.1073/pnas.2120617119","title":"Loss of glucose 6-phosphate dehydrogenase function increases oxidative stress and glutaminolysis in metastasizing melanoma cells","abstract":"<jats:title>Significance</jats:title>\n                  <jats:p>\n                    Melanoma metastasis is limited by oxidative stress. Cells that enter the blood experience high levels of reactive oxygen species and usually die of ferroptosis. We found that melanoma cells become more dependent upon the oxidative pentose phosphate pathway to manage oxidative stress during metastasis. When pentose phosphate pathway function was impaired by reduced glucose 6-phosphate dehydrogenase (\n                    <jats:italic>G6PD</jats:italic>\n                    ) function, melanoma cells increased malic enzyme activity and glutamine consumption. Melanoma cells thus have redundant and layered protection against oxidative stress.\n                  </jats:p>","journal":"Proceedings of the National Academy of Sciences","year":2022,"id":595369,"datarank":0.6814942173405006,"base_score":4.543294782270004,"endowment":4.543294782270004,"self_citation_contribution":0.6814942173405006,"citation_network_contribution":0.0,"self_endowment_contribution":0.6814942173405006,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":93,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":815367,"name":"Vishal Khivansara","orcid":"0000-0003-2574-5298","position":1,"is_corresponding":false},{"id":815826,"name":"Ashley Leach","orcid":null,"position":2,"is_corresponding":false},{"id":815368,"name":"Jennifer G. 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When pentose phosphate pathway function was impaired by reduced glucose 6-phosphate dehydrogenase (\n                    <jats:italic>G6PD</jats:italic>\n                    ) function, melanoma cells increased malic enzyme activity and glutamine consumption. Melanoma cells thus have redundant and layered protection against oxidative stress.\n                  </jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35110412","pmcid":"PMC8833200","openalex_id":null,"authors":[],"funders":[{"funder_name":"Howard Hughes Medical Institute","grant_id":"none","title":null},{"funder_name":"Cancer Prevention and Research Institute of Texas","grant_id":"RP170114","title":null},{"funder_name":"HHS | NIH | National Cancer Institute","grant_id":"CA228608","title":null},{"funder_name":"NIAMS NIH HHS","grant_id":"T32 AR065969","title":null},{"funder_name":"NCI NIH HHS","grant_id":"U01 CA228608","title":null},{"funder_name":"National Institutes of Health","grant_id":"5U01CA228608-03","title":"The Metabolic Regulation of Melanoma Metastasis"},{"funder_name":"National Institutes of Health","grant_id":"5T32AR065969-09","title":"Dermatology Research Training Program"},{"funder_name":"Howard Hughes Medical Institute","grant_id":"","title":null}],"total_grants":8,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1073/pnas.2120617119","host_type":"publisher"},{"url":"http://www.pnas.org/syndication/doi/10.1073/pnas.2120617119","host_type":"publisher"},{"url":"https://pnas.org/doi/pdf/10.1073/pnas.2120617119","host_type":"publisher"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8833200","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC8833200","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC8833200?pdf=render","host_type":"Europe_PMC"},{"url":"https://www.pnas.org/content/pnas/119/6/e2120617119.full.pdf","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/35110412","host_type":""},{"url":"http://dx.doi.org/10.1073/pnas.2120617119","host_type":""},{"url":"https://www.ncbi.nlm.nih.gov/pubmed/35110412","host_type":""},{"url":"https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85123973797","host_type":""}],"fields_of_study":["0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Animals","Mice, Inbred NOD","Humans","Mice","Melanoma","Reactive Oxygen Species","NADP","Glucosephosphate Dehydrogenase","Glutamine","Oxidation-Reduction","Oxidative Stress","Pentose Phosphate Pathway"],"keywords":["Melanoma","Oxidative stress","Metastasis","Pentose phosphate pathway","Glutaminolysis","Glutamine","Medizin","Biological Sciences","Glucosephosphate Dehydrogenase","Mice","Mice, Inbred NOD","Animals","Humans","Reactive Oxygen Species","Oxidation-Reduction","NADP"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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