{"doi":"10.1073/pnas.2120336119","title":"A vasculature niche orchestrates stromal cell phenotype through PDGF signaling: Importance in human fibrotic disease","abstract":"<jats:title>Significance</jats:title>\n                  <jats:p>Tissue fibrotic diseases, for example of the liver and lung, represent a huge unmet medical need. In this study, using single-cell RNA sequencing, cytometry by time of flight (CyTOF), tissue imaging, and functional assays, we identify a complex vascular niche in Dupuytren’s disease (DD), a common localized fibrotic condition of the palm, where early-disease-stage tissue can be accessed readily. We uncover a population of myofibroblast precursors within the pericyte compartment and demonstrate that the endothelium instructs the differentiation of functionally distinct stromal cells, thereby orchestrating discrete microenvironments in the fibrotic milieu. Together, these findings provide a basis for the concept of targeting blood vessel signaling to control the progression of human fibrosis.</jats:p>","journal":"Proceedings of the National Academy of Sciences","year":2022,"id":608948,"datarank":0.9182606555158657,"base_score":3.332204510175204,"endowment":3.332204510175204,"self_citation_contribution":0.49983067652628066,"citation_network_contribution":0.41842997898958495,"self_endowment_contribution":0.49983067652628066,"citer_contribution":0.41842997898958495,"corpus_percentile":null,"corpus_rank":null,"citation_count":27,"citer_count":23,"citers_with_citation_signal":17,"citers_with_endowment":17,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1564667,"name":"Lynn Williams","orcid":null,"position":1,"is_corresponding":false},{"id":788770,"name":"Nan Yang","orcid":"0000-0002-1610-5240","position":2,"is_corresponding":false},{"id":148929,"name":"Mingjun Zhang","orcid":null,"position":3,"is_corresponding":false},{"id":1564668,"name":"Carl Lee","orcid":null,"position":4,"is_corresponding":false},{"id":104269,"name":"Marc Feldmann","orcid":"0000-0003-0800-7840","position":5,"is_corresponding":false},{"id":1525569,"name":"Glenda Trujillo","orcid":null,"position":6,"is_corresponding":false},{"id":895898,"name":"Dominic Furniss","orcid":"0000-0003-2780-7173","position":7,"is_corresponding":false},{"id":401400,"name":"Jagdeep Nanchahal","orcid":"0000-0002-9579-9411","position":8,"is_corresponding":false},{"id":1564666,"name":"Thomas B. Layton","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A vasculature niche orchestrates stromal cell phenotype through PDGF signaling: Importance in human fibrotic disease","abstract":"<jats:title>Significance</jats:title>\n                  <jats:p>Tissue fibrotic diseases, for example of the liver and lung, represent a huge unmet medical need. In this study, using single-cell RNA sequencing, cytometry by time of flight (CyTOF), tissue imaging, and functional assays, we identify a complex vascular niche in Dupuytren’s disease (DD), a common localized fibrotic condition of the palm, where early-disease-stage tissue can be accessed readily. We uncover a population of myofibroblast precursors within the pericyte compartment and demonstrate that the endothelium instructs the differentiation of functionally distinct stromal cells, thereby orchestrating discrete microenvironments in the fibrotic milieu. Together, these findings provide a basis for the concept of targeting blood vessel signaling to control the progression of human fibrosis.</jats:p>","is_dataset_classified":null,"base_score":3.332204510175204,"endowment":3.332204510175204,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35320046","pmcid":"PMC9060460","openalex_id":"https://openalex.org/W4220905187","authors":[],"funders":[{"funder_name":"Royal College of Surgeons of England","grant_id":"AZR0010","title":null},{"funder_name":"British Society for Surgery of the Hand","grant_id":"AZR01250","title":null},{"funder_name":"Kennedy Trust","grant_id":"KENN202117","title":null},{"funder_name":"Kennedy Trust","grant_id":"KENN161710","title":null},{"funder_name":"Kennedy Institute","grant_id":"AZT00040-AZ06 (Carl)","title":null},{"funder_name":"Kennedy Trust","grant_id":"KENN202103","title":null},{"funder_name":"Wellcome Trust","grant_id":"unidentified","title":"unidentified"},{"funder_name":"Wellcome Trust","grant_id":"","title":null}],"total_grants":8,"fwci":3.9065,"citation_percentile":0.94240965,"influential_citations":0,"citation_trend":[{"year":2022,"count":3},{"year":2023,"count":11},{"year":2024,"count":6},{"year":2025,"count":4},{"year":2026,"count":3}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1073/pnas.2120336119","host_type":"journal"},{"url":"https://doi.org/10.1073/pnas.2120336119","host_type":"publisher"},{"url":"https://pnas.org/doi/pdf/10.1073/pnas.2120336119","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/35320046","host_type":"repository"},{"url":"https://ora.ox.ac.uk/objects/uuid:8fd14093-a11e-4847-ab09-0a6d765a8531","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9060460","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC9060460","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC9060460?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1073/pnas.2120336119","host_type":""}],"fields_of_study":["Dupuytren's Contracture and Treatments","Genetic factors in colorectal cancer","Tumors and Oncological Cases","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Dupuytren Contracture","Fibrosis","Humans","Phenotype","Stromal Cells","Myofibroblasts","Tumor Microenvironment"],"keywords":["Myofibroblast","Stromal cell","Pericyte","Pathology","Biology","Phenotype","Fibrosis","Mesenchymal stem cell","Population","Lung","Cell biology","Cancer research","Medicine","Endothelial stem cell","Genetics","Gene","Inflammation","PDGF","Vasculature","Single-cell Sequencing","Dupuytren Contracture","Tumor Microenvironment","Humans","Biological Sciences","Stromal Cells","Myofibroblasts"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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